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SDAP - All Allergens
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Ovidiu Ivanciuc      Submit new allergen information to SDAP
Last Updated: February 25, 2013  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Access to SDAP is available free of charge for Academic and non-profit use.
Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu).
Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen Bos d 4

Translate to AllerML
AllergenBos d 4
Typefoods
Species - Systematic NameBos domesticus
Species - Common Namedomestic cattle
Keywordsalpha-lactalbumin; Lactose synthase B protein
ClassIUIS

Bos d 4 - PubMedReference
Reference 1Hurley WL, Schuler LA. Molecular cloning and nucleotide sequence of a bovine alpha-lactalbumin cDNA. Gene. 1987;61(1):119-22.
Reference 2Wang M, Scott WA, Rao KR, Udey J, Conner GE, Brew K. Recombinant bovine alpha-lactalbumin obtained by limited proteolysis of a fusion protein expressed at high levels in Escherichia coli. J Biol Chem. 1989 Dec 15;264(35):21116-21.
Reference 3Vilotte JL, Soulier S, Mercier JC, Gaye P, Hue-Delahaie D, Furet JP. Complete nucleotide sequence of bovine alpha-lactalbumin gene: comparison with its rat counterpart. Biochimie. 1987 Jun-Jul;69(6-7):609-20.
Reference 4Brew K, Castellino FJ, Vanaman TC, Hill RL. The complete amino acid sequence of bovine alpha-lactalbumin. J Biol Chem. 1970 Sep 10;245(17):4570-82.
Reference 5Shewale JG, Sinha SK, Brew K. Evolution of alpha-lactalbumins. The complete amino acid sequence of the alpha-lactalbumin from a marsupial (Macropus rufogriseus) and corrections to regions of sequence in bovine and goat alpha-lactalbumins. J Biol Chem. 1984 Apr 25;259(8):4947-56.
Reference 6Bleck GT, Bremel RD. Sequence and single-base polymorphisms of the bovine alpha-lactalbumin 5'-flanking region. Gene. 1993 Apr 30;126(2):213-8.
Reference 7Pike AC, Brew K, Acharya KR. Crystal structures of guinea-pig, goat and bovine alpha-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthase. Structure. 1996 Jun 15;4(6):691-703.
Reference 8Viaene A, Volckaert G, Joniau M, De Baetselier A, Van Cauwelaert F. Efficient expression of bovine alpha-lactalbumin in Saccharomyces cerevisiae. Eur J Biochem. 1991 Dec 5;202(2):471-7.

Bos d 4 - Protein Sequences
SourceLink to SourceView SequenceFASTA@SDAPBLAST@NCBIBLAST@ExPASyPROSITE@PIR
SwissProtP00711Go!Go!Go!Go!Go!
GenBank295774Go!Go!Go!Go!Go!
SwissProtQ28049Go!Go!Go!Go!Go!
FASTA@SDAP: FASTA search against all SDAP allergen sequences performed at SDAP
BLAST@ExPASy: BLAST search performed at the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)
PROSITE@PIR: PROSITE search performed at PIR - Protein Information Resources

Bos d 4 - Protein Sequence Properties
Protein SequenceProtease cleavage sites
PeptideCutter@ExPASy
P00711Go!
295774Go!
Q28049Go!
PeptideCutter@ExPASy: Protease cleavage sites predicted with PeptideCutter from the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)

Bos d 4 - Protein Similarity, Classification and Clustering
Protein SequenceSuperfamilyInterPro
P00711Go!Go!
Q28049Go!Go!

Bos d 4 - Protein Models
3D ModelSourceLink to SourceView SequenceView AlignmentGet ModelPicturePicture+90Picture+180Picture+270Jmol
Model 71SwissProtP00711Go!Go!Go!Go!Go!Go!Go!View!
Model 564GenBank295774Go!Go!Go!Go!Go!Go!Go!View!
Model 808SwissProtQ28049Go!Go!Go!Go!Go!Go!Go!View!
These 3D allergen models are superseded by newer PDB structures.

Bos d 4 - Pfam domains
SequencePfam sequencePfam familyAllergens from
this Pfam family
Pfam databasePfam regionFirst amino acidLast amino acid
P00711       
 LCA_BOVINPF00062Go!Pfam A120139
  PF00062: C-type lysozyme/alpha-lactalbumin family
295774       
 LALBA_BOVINPF00062Go!Pfam A120139
  PF00062: C-type lysozyme/alpha-lactalbumin family
Q28049       
 Q28049_BOVINPF00062Go!Pfam A11120
  PF00062: C-type lysozyme/alpha-lactalbumin family
Pfam is a database of multiple sequence alignments and hidden Markov models covering protein domains and families

Inspect MotifMate results for Bos d 4. AutoMotif contains a database of PCPMer motifs for allergens.
MotifMate home page
MotifMate summary
Browse MotifMate proteins
Browse MotifMate families

Bos d 4 - Sequences from the Entrez Nucleotides database
Link to GenBankView Sequence
163282Go!

Bos d 4 - PDB Structures
PDB AccessionJmolDeposition dateExperimentalObservation
1HFZView!13-JUN-96X-ray diffraction resolution 2.3 Ainserted (MET 1X), mutant M90V
2G4NView!2006-02-22X-ray diffraction resolution 2.30 A 


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