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SDAP - All Allergens
| | Allergen Cry j 1Translate to AllerML | | | | | Allergen | Cry j 1 | | Type | tree | | Species - Systematic Name | Pinales; Cryptomeria japonica | | Species - Common Name | Japanese cedar, sugi | | Keywords | pectate lyase; SBP/ Sugi basic protein
| | Class | IUIS |
| |
| Cry j 1 - PubMed | Reference | | Reference 1 | Taniai M, Ando S, Usui M, Kurimoto M, Sakaguchi M, Inouye S, Matuhasi T N-terminal amino acid sequence of a major allergen of Japanese cedar pollen (Cry j I). FEBS Lett. 1988 Nov 7;239(2):329-32. | | Reference 2 | Sone T, Komiyama N, Shimizu K, Kusakabe T, Morikubo K, Kino K. Cloning and sequencing of cDNA coding for Cry j I, a major allergen of Japanese cedar pollen. Biochem Biophys Res Commun. 1994 Mar 15;199(2):619-25. | | Reference 3 | Sone T, Morikubo K, Miyahara M, Komiyama N, Shimizu K, Tsunoo H, Kino K. T cell epitopes in Japanese cedar (Cryptomeria japonica) pollen allergens: choice of major T cell epitopes in Cry j 1 and Cry j 2 toward design of the peptide-based immunotherapeutics for the management of Japanese cedar pollinosis. J Immunol. 1998 Jul 1;161(1):448-57. | | Reference 4 | Taniguchi Y, Ono A, Sawatani M, Nanba M, Kohno K, Usui M, Kurimoto M, Matuhasi T. Cry j I, a major allergen of Japanese cedar pollen, has pectate lyase enzyme activity. Allergy. 1995 Jan;50(1):90-3. | | Reference 5 | Hijikata A, Matsumoto I, Kojima K, Ogawa H. Antigenicity of the oligosaccharide moiety of the Japanese cedar (Cryptomeria japonica) pollen allergen, Cry jI. Int Arch Allergy Immunol. 1994 Oct;105(2):198-202. | | Reference 6 | Hino K, Yamamoto S, Sano O, Taniguchi Y, Kohno K, Usui M, Fukuda S, Hanzawa H, Haruyama H, Kurimoto M. Carbohydrate structures of the glycoprotein allergen Cry j I from Japanese cedar (Cryptomeria japonica) pollen. J Biochem (Tokyo). 1995 Feb;117(2):289-95. | | Reference 7 | Tamura Y, Sasaki R, Inouye S, Kawaguchi J, Serizawa N, Toda M, Takemori T, Sakaguchi M. Identification of a sequential B-cell epitope on major allergen (Cry j 1) of Japanese cedar (Cryptomeria japonica) pollen in mice. Int Arch Allergy Immunol. 2000 Nov;123(3):228-35. | | Reference 8 | Kingetsu I, Ohno N, Hayashi N, Sakaguchi M, Inouye S, Saito S. Common antigenicity between Japanese cedar (Cryptomeria japonica) pollen and Japanese cypress (Chamaecyparis obtusa) pollen, I. H-2 complex affects cross responsiveness to Cry j 1 and Cha o 1 at the T- and B-cell level in mice. Immunology. 2000 Apr;99(4):625-9. | | Reference 9 | Masuda K, Sakaguchi M, Saito S, Yasueda H, Iwabuchi S, Tsukui T, Hayashi N, Nakao Y, Kurata K, Maeda S, Ohno K, Tsujimoto H. Identification of peptides containing T-cell epitopes of Japanese cedar (Cryptomeria japonica) pollen allergen (Cry j 1) in dogs. Vet Immunol Immunopathol. 2004 Nov;102(1-2):45-52. | | Reference 10 | Hirahara K, Tatsuta T, Takatori T, Ohtsuki M, Kirinaka H, Kawaguchi J, Serizawa N, Taniguchi Y, Saito S, Sakaguchi M, Inouye S, Shiraishi A. Preclinical evaluation of an immunotherapeutic peptide comprising 7 T-cell determinants of Cry j 1 and Cry j 2, the major Japanese cedar pollen allergens. J Allergy Clin Immunol. 2001 Jul;108(1):94-100. | | Reference 11 | Sakaguchi M, Masuda K, Toda M, Inouye S, Yasueda H, Taniguchi Y, Nagoya T, DeBoer DJ, Tsujimoto H. Analysis of the canine IgE-binding epitope on the major allergen (Cry j 1) of Japanese cedar pollen with anti-Cry j 1 monoclonal antibodies. Vet Immunol Immunopathol. 2001 Jan 10;78(1):35-43. | | Reference 12 | Sakaguchi M, Hashimoto M, Nigi H, Yasueda H, Takahashi Y, Watanabe M, Nagoya T, Taniguchi Y, Kurimoto M, Inouye S. Epitope specificity of IgE antibodies to a major allergen (Cry j 1) of Japanese cedar pollen in sera of humans and monkeys with pollinosis. Immunology. 1997 Jun;91(2):161-6. | | Reference 13 | Toda M, Sato H, Takebe Y, Taniguchi Y, Saito S, Inouye S, Takemori T, Sakaguchi M. Inhibition of immunoglobulin E response to Japanese cedar pollen allergen (Cry j 1) in mice by DNA immunization: different outcomes dependent on the plasmid DNA inoculation method. Immunology. 2000 Feb;99(2):179-86. | | Reference 14 | Taniai M, Kayano T, Takakura R, Yamamoto S, Usui M, Ando S, Kurimoto M, Panzani R, Matuhasi T. Epitopes on Cry j I and Cry j II for the human IgE antibodies cross-reactive between Cupressus sempervirens and Cryptomeria japonica pollen. Mol Immunol. 1993 Feb;30(2):183-9. | | Reference 15 | Ogawa H, Hijikata A, Amano M, Kojima K, Fukushima H, Ishizuka I, Kurihara Y, Matsumoto I. Structures and contribution to the antigenicity of oligosaccharides of Japanese cedar (Cryptomeria japonica) pollen allergen Cry j I: relationship between the structures and antigenic epitopes of plant N-linked complex-type glycans. Glycoconj J. 1996 Aug;13(4):555-66. | | Reference 16 | Goto Y, Kondo T, Ide T, Yasueda H, Kuramoto N, Yamamoto K. Cry j 1 isoforms derived from Cryptomeria japonica trees have different binding properties to monoclonal antibodies. Clin Exp Allergy. 2004 Nov;34(11):1754-61. |
Cry j 1 - Isoallergens
Cry j 1 - Epitopes| No | Epitope | Exact
Match
@SDAP | Peptide
Similarity
@SDAP | Exact
Match
@PIR | Position | Type | Description | | 1 | QNRMKLADCAVGFGS | Go! | Go! | Go! | 37-51 | T-cell | recognized by 11 out of 18 individuals
| | 2 | RPLWIIFSGNMNIKL | Go! | Go! | Go! | 87-101 | T-cell | recognized by 9 out of 18 individuals
| | 3 | KMPMYIAGYKTFDGR | Go! | Go! | Go! | 102-116 | T-cell | recognized by 11 out of 18 individuals
| | 4 | TFDGRGAQVYIGNGG | Go! | Go! | Go! | 112-126 | T-cell | recognized by 9 out of 18 individuals
| | 5 | PCVFIKRVSNVIIHG | Go! | Go! | Go! | 127-141 | T-cell | recognized by 13 out of 18 individuals
| | 6 | KRVSNVIIHGLHLYG | Go! | Go! | Go! | 132-146 | T-cell | recognized by 10 out of 18 individuals
| | 7 | KSMKVTVAFNQFGPN | Go! | Go! | Go! | 232-246 | T-cell | recognized by 13 out of 18 individuals
| | 8 | DVFYNGAYFVSSGKY | Go! | Go! | Go! | 322-336 | T-cell | recognized by 10 out of 18 individuals
| | 9 | EGGNIYTKKEAFNVE | Go! | Go! | Go! | 337-351 | T-cell | recognized by 9 out of 18 individuals
|
T. Sone, K. Morikubo, M. Miyahara, N. Komiyama, K. Shimizu, H. Tsunoo, and K. Kino,
T cell epitopes in Japanese cedar (Cryptomeria japonica) pollen allergens:
choice of major T cell epitopes in Cry j 1 and Cry j 2 toward design of the
peptide-based immunotherapeutics for the management of Japanese cedar pollinosis.
J. Immunol. 1998, 161, 448-457.
|
