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Department of Biochemistry and Molecular Biology Sealy Center for Structural Biology Computational Biology



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                SDAP 2.0 - Structural Database of Allergenic Proteins
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Werner Braun      Submit new allergen information to SDAP
  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Access to SDAP is available free of charge for Academic and non-profit use.< Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu). Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen Info Description
Allergen ID 331
Allergen Scientific Name Act d 1
Allergen Species - Systematic Name Actinidia deliciosa
Allergen Species - Common Name Kiwi fruit
Allergen Common source foods
Allergen Common name
Allergen Keywords Cysteine protease; EC 3.4.22.14; Old Name: Act c 1
Allergen IUIS (Yes=1, No=0) 1
ID Allergen Name
Act d 1 - References
ID Reference
Pubmed ID: 9564807
Pastorello EA, Conti A, Pravettoni V, Farioli L, Rivolta F, Ansaloni R, Ispano M, Incorvaia C, Giuffrida MG, Ortolani C, Identification of actinidin as the major allergen of kiwi fruit. J Allergy Clin Immunol. 1998 Apr;101(4 Pt 1):531-7.
Act d 1 - Protein Sequences
Source Link to source
SwissProt P00785
GenBank 166317
Act d 1 - PDB Structure
PDB Id PDB Name PDB Entry Deposition Date Experiment Type Observation
331 1 2ACT 27-NOV-79 X-ray diffraction resolution 1.7 A
331 231 1AEC 1992-02-05 X-ray diffraction resolution 1.86 A
1AEC.pdb


Act d 1 - Theoretical Model Structure
Model ID PDB file PDB Snapshot PDB Snapshot 90 PDB Snapshot 180 PDB Snapshot 270 3D PDB View
2 GetModel Model Pic Model Pic Model Pic Model Pic Click here
615 GetModel Model Pic Model Pic Model Pic Model Pic Click here
Act d 1 - Sequence Search :
Sequence Header Sequence
Act d 1
SDAP Sequence ID: 2
SDAP Allergen ID: 331
MGLPKSFVSMSLLFFSTLLILSLAFNAKNLTQRTNDEVKAMYESWLIKYGKSYNSLGEWERRFEIFKETLRFIDEHNADTNRSYKVGLNQFADLTDEEFRSTYLGFTSGSNKTKVSNRYEPRFGQVLPSYVDWRSAGAVVDIKSQGECGGCWAFSAIATVEGINKIVTGVLISLSEQELIDCGRTQNTRGCNGGYITDGFQFIINNGGINTEENYPYTAQDGECNLDLQNEKYVTIDTYENVPYNNEWALQTAVTYQPVSVALDAAGDAFKHYSSGIFTGPCGTAIDHAVTIVGYGTEGGIDYWIVKNSWDTTWGEEGYMRILRNVGGAGTCGIATMPSYPVKYNNQNHPKPYSSLINPPAFSMSKDGPVGVDDGQRYSA
View 3D Structure Click here to view 3D model structure of allergen
Fasta Search in SDAP
Blast Swissprot database search at NCBI
Blast PDB database search at NCBI
Blast NR database search at NCBI
Act d 1
SDAP Sequence ID: 615
SDAP Allergen ID: 331
MGLPKSFVSMSLLFFSTLLILSLAFNAKNLTQRTNDEVKAMYESWLIKYGKSYNSLGEWERRFEIFKETLRFIDEHNADTNRSYKVGLNQFADLTDEEFRSTYLGFTSGSNKTKVSNRYEPRVGQVLPSYVDWRSAGAVVDIKSQGECGGCWAFSAIATVEGINKIVTGVLISLSEQELIDCGRTQNTRGCNGGYITDGFQFIINNGGINTEENYPYTAQDGECNVELQNEKYVTIDTYENVPYNNEWALQTAVTYQPVSVALDAAGDAFKQYSSGIFTGPCGTAIDHAVTIVGYGTEGGIDYWIVKNSWDTTWGEEGYMRILRNVGGAGTCGIATMPSYPVKYNNQNYPEPYSSLINPPAFSMSKDGPVGVEDGQRYSA
View 3D Structure Click here to view 3D model structure of allergen
Fasta Search in SDAP
Blast Swissprot database search at NCBI
Blast PDB database search at NCBI
Blast NR database search at NCBI
Act d 1 - Statistics from Alphafold ( SI is sequence id, Best template format: PDB_ChainID)
Allergen Name pLDDT Score pTM Score Best PDB template %Seq ID Align length Seq length Query Range Sequence Range E-Value Bit Score Download Model
Act d 1 87.9 0.79 1AEC_A 99.541 218 380 127 - 344 1 - 218 0 449 Download (SI: 615)
Act d 1 87.65 0.78 1AEC_A 99.083 218 380 127 - 344 1 - 218 0 449 Download (SI: 2)
Act d 1 - Alphafold Theoretical Model Structure
Model Structure
615_relaxed_rank_1_model_4.pdb


Coverage Plddt
Act d 1 - Protein Sequence Properties!
Protein Sequence Protease cleavage sites PeptideCutter at ExPASy
P00785 Click here to process the data
166317 Click here to process the data
Act d 1 - PFAM Information
SeqID Aller ID AlnS AlnE EnvS EnvE PFAM ID Family Type Clan Description
2 331 42 99 42 99 PF08246 Inhibitor_I29 Domain No_clan Cathepsin propeptide inhibitor domain (I29)
2 331 127 342 127 342 PF00112 Peptidase_C1 Domain CL0125 Papain family cysteine protease
615 331 42 99 42 99 PF08246 Inhibitor_I29 Domain No_clan Cathepsin propeptide inhibitor domain (I29)
615 331 127 342 127 342 PF00112 Peptidase_C1 Domain CL0125 Papain family cysteine protease
Where: AlnS= Alignment start position, AlnE= Alignment end position, EnvS= Envelope start position, EnvE= Envelope end position.

List of B-cell epitopes predicted by BepiPred method using a window size of 9 amino acids

Cleck here for epitopes predicted by BepiPred method
Act d 1 - Epitope Information from published data
No. Position Epitope Sequence Epitope Type View epitope Search epitope in SDAP PD search in SDAP Cross-React search
No epitope information found!
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