The University of Texas Medical Branch
Department of Biochemistry and Molecular Biology Sealy Center for Structural Biology Computational Biology



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                SDAP - Structural Database of Allergenic Proteins
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Werner Braun      Submit new allergen information to SDAP
  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Access to SDAP is available free of charge for Academic and non-profit use.
Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu).
Secure access to SDAP is available from https://fermi.utmb.edu/SDAP
Allergen Info Description
Allergen ID 201
Allergen Scientific Name Aed a 2
Allergen Species - Systematic Name Aedes aegyptii
Allergen Species - Common Name mosquito
Allergen Common source insects
Allergen Common name
Allergen Keywords N
Allergen IUIS (Yes=1, No=0) 1
ID Allergen Name
Aed a 2 - References
ID Reference
No reference found!
Aed a 2 - Protein Sequences
Source Link to source
SwissProt P18153
GenBank 159559
Aed a 2 - PDB Structure
PDB Id PDB Name PDB Entry Deposition Date Experiment Type Observation
201 200 3DXL 2008-07-24 X-ray diffraction resolution 1.30 A
201 201 3DY9 2008-07-25 X-ray diffraction resolution 1.70 A
201 202 3DYE 2008-07-27 X-ray diffraction resolution 1.75 A
201 203 3DZT 2008-07-30 X-ray diffraction resolution 1.80 A
3DZT.pdb


Aed a 2 - Theoretical Model Structure
Model ID PDB file PDB Snapshot PDB Snapshot 90 PDB Snapshot 180 PDB Snapshot 270 3D PDB View
4 GetModel Model Pic Model Pic Model Pic Model Pic Click here
356 GetModel Model Pic Model Pic Model Pic Model Pic Click here
Aed a 2 - Sequence Search
Sequence Header Sequence
Aed a 2
SDAP Sequence ID: 356
SDAP Allergen ID: 201
MKLPLLLAIVTTFSVVASTGPFDPEEMLFTFTRCMEDNLEDGPNRLPMLAKWKEWINEPVDSPATQCFGKCVLVRTGLYDPVAQKFDASVIQEQFKAYPSLGEKSKVEAYANAVQQLPSTNNDCAAVFKAYDPVHKAHKDTSKNLFHGNKELTKGLYEKLGKDIRQKKKSYFEFCENKYYPAGSDKRQQLCKIRQYTVLDDALFKEHTDCVMKGIRYITKNNELDAEEVKRDFKLVNKDTKALEKVLNDCKSKEPSNAKEKSWHYYKCLVESSVKDDFKEAFDYREVRSQIYAFNLPKKQAYSKPAVQSQVMEIDGKQCPQ
View 3D Structure Click here to view 3D model structure of allergen
Fasta Search in SDAP
Blast Swissprot database search at NCBI
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Blast NR database search at NCBI
Expasy Blast Search
Aed a 2
SDAP Sequence ID: 4
SDAP Allergen ID: 201
MKLLLLLAIFTTFSVVASMGPFDPEEMLFIFTRCMEDNLEDGANRLPMLAKWKEWINEPVDSPATQCFGKCVLVRTGLYDPVAQKFDASVIQEQFKAYPSLGEKSKVEAYANAVKQLPSTNNDCAAVFKAYDPVHKAHKDTSKNLFHGNKELTKGLYEKLGKDIRQKKQSYFEFCENKYYPAGSDKRQQLCQIRQYTVLDDALFKEHTDCVMKGIRYITKDNQLDVEEVKRDFKLVNKDTKALEKVLNDCKSKEPSNAKEKSWHYYKCLVESSVKDDFKEAFDYREVRSQIYAFNLPKKQAYSKPAVQSQVMEIDGKQCPQ
View 3D Structure Click here to view 3D model structure of allergen
Fasta Search in SDAP
Blast Swissprot database search at NCBI
Blast PDB database search at NCBI
Blast NR database search at NCBI
Expasy Blast Search
Aed a 2 - Statistics from Alphafold ( SI is sequence id, Best template format: PDB_ChainID)
Allergen Name pLDDT Score pTM Score Best PDB template %Seq ID Align length Seq length Query Range Sequence Range E-Value Bit Score Download Model
Aed a 2 93.9 0.83 3DXL_A 96.689 302 321 20 - 321 2 - 303 0 613 Download (SI: 356)
Aed a 2 93.95 0.83 3DXL_A 99.34 303 321 19 - 321 1 - 303 0 629 Download (SI: 4)
Aed a 2 - Alphafold Theoretical Model Structure
Model Structure
4_relaxed_rank_1_model_1.pdb


Coverage Plddt
Aed a 2 - Protein Sequence Properties!
Protein Sequence Protease cleavage sites PeptideCutter at ExPASy
P18153 Click here to process the data
159559 Click here to process the data
Aed a 2 - PFAM Information
SeqID Aller ID AlnS AlnE EnvS EnvE PFAM ID Family Type Clan Description
4 201 57 131 24 137 PF01395 PBP_GOBP Domain No_clan PBP/GOBP family
4 201 165 271 158 272 PF01395 PBP_GOBP Domain No_clan PBP/GOBP family
356 201 58 131 31 137 PF01395 PBP_GOBP Domain No_clan PBP/GOBP family
356 201 164 271 158 272 PF01395 PBP_GOBP Domain No_clan PBP/GOBP family
Where: AlnS= Alignment start position, AlnE= Alignment end position, EnvS= Envelope start position, EnvE= Envelope end position.

Welcome

Predicted B-Cell epitope using BCEP method for Aed a 2

Probe radius : 1.400

POLAR area/energy = 6158.68

APOLAR area/energy = 11062.74

Total area/energy = 17221.42

Number of surface atoms = 1500

Number of buried atoms = 1102

Residues Predicted with high probability (in top five patches) are: 45,297,298,299,300,316,319,320,321,157,161,164,166,167,168,169,174,171,173,290,84,85,118,119,120,283,304 , and medium probability (next top five patches) are : 304,305,306,308,309,310,311,312,291,313,314,315,317,318,77,87,89,92,93,205,209,260,261,263,264,266,267 . Predicted residues are shown in red and green color stick representation.

Original PDB file 1960.test.pdb
Original PDB file with surface residue only. All amino acid residue are replaced by their CB atom, in case of GLY CA atom is used. Solvent accessible surface area of each residue is stored in last column of the PDB file. 11960.test.txt
Patch drawn around the residues by patch analysis are stored in this file
How to read: Col 1: Patch No. Col 2: Center Res Name. Col 3: Sum(Pint*Area), Col 4: Sum(Psur*Area), Col 5: Total Residue, Col 6: Interface score, Col 7: Surface Score, Col 8: Max Interface Score, Col 9: Minimum Interface Score
1960.test.tmppat
Residues predicted by patch analysis are stored in this file.
How to read: Col 1: Patch No. Col 2: Center Res Name. Col 3: Res Number Col 4: Neigbouring Res Name, Col 5: Sum(Pint*Area). Col 6: Sum(PSur*Area), Col 7: Sum(Area), Col 8: Similar no of residue in patch (e.g CYS, CYS = 2)
1960.test.res
All residues scored by patch analysis are stored in this file.
How to read: Col 1: Patch No. Col 2: Center Res Name. Col 3: Sum(Pint*Area)/sum(Area), Col 4: Sum(Psur*Area)/sum(Area), Col 5: Total Residue
1960.test.resALL

[For BCEP predicted results, please cite our websites http://fermi.utmb.edu/ http://curie.utmb.edu/ for your future publications (Negi et al., Bioinformatics, 23, 3397-3399, 2007 , Negi et al., J. Mol. Model., 13, 1157-1167, 2007; Negi et al., J. Mol. Model., 12, 921-929, 2006)]



List of B-cell epitopes predicted by BepiPred method using a window size of 9 amino acids
Peptides predicted from BepiPred method can be used to search related peptides in SDAP using PD search and Cross-React method.
Please note: BepiPred Epitopes are predicted using BepiPred webserver implemented in IEDB Analysis Resource at http://tools.iedb.org/main/bcell/
Cleck here for epitopes predicted by BepiPred method

Aed a 2 - Epitope Information from published data
No. Position Epitope Sequence Epitope Type View epitope Search epitope in SDAP PD search in SDAP Cross-React search
No epitope information found!
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