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                SDAP 2.0 - Structural Database of Allergenic Proteins
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Werner Braun      Submit new allergen information to SDAP
  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Access to SDAP is available free of charge for Academic and non-profit use.< Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu). Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen Info Description
Allergen ID 150
Allergen Scientific Name Asp f 2
Allergen Species - Systematic Name Aspergillus fumigatus
Allergen Species - Common Name
Allergen Common source fungi (moulds)
Allergen Common name Ascomycota Eurotiales
Allergen Keywords ASPND1
Allergen IUIS (Yes=1, No=0) 1
ID Allergen Name
Asp f 2 - References
ID Reference
Pubmed ID: 12391230
Banerjee B, Kurup VP, Greenberger PA, Kelly KJ, Fink JN, C-terminal cysteine residues determine the IgE binding of Aspergillus fumigatus allergen Asp f 2. J Immunol. 2002 Nov 1;169(9):5137-44.
Pubmed ID: 10225885
Banerjee B, Greenberger PA, Fink JN, Kurup VP, Conformational and linear B-cell epitopes of Asp f 2, a major allergen of Aspergillus fumigatus, bind differently to immunoglobulin E antibody in the sera of allergic bronchopulmonary aspergillosis patients. Infect Immun. 1999 May;67(5):2284-91.
Pubmed ID: 9784519
Banerjee B, Greenberger PA, Fink JN, Kurup VP. Immunological characterization of Asp f 2, a major allergen from Aspergillus fumigatus associated with allergic bronchopulmonary aspergillosis. Infect Immun. 1998 Nov;66(11):5175-82.
Asp f 2 - Protein Sequences
Source Link to source
SwissProt P79017
Asp f 2 - Theoretical Model Structure
Model ID PDB file PDB Snapshot PDB Snapshot 90 PDB Snapshot 180 PDB Snapshot 270 3D PDB View
39 GetModel Model Pic Model Pic Model Pic Model Pic Click here
Asp f 2 - Sequence Search :
Sequence Header Sequence
Asp f 2
SDAP Sequence ID: 39
SDAP Allergen ID: 150
MAALLRLAVLLPLAAPLVATLPTSPVPIAARATPHEPVFFSWDAGAVTSFPIHSSCNATQRRQIEAGLNEAVELARHAKAHILRWGNESEIYRKYFGNRPTMEAVGAYDVIVNGDKANVLFRCDNPDGNCALEGWGGHWRGANATSETVICDRSYTTRRWLVSMCSQGYTVAGSETNTFWASDLMHRLYHVPAVGQGWVDHFADGYDEVIALAKSNGTESTHDSEAFEYFALEAYAFDIAAPGVGCAGESHGPDQGHDTGSASAPASTSTSSSSSGSGSGATTTPTDSPSATIDVPSNCHTHEGGQLHCT
View 3D Structure Click here to view 3D model structure of allergen
Fasta Search in SDAP
Blast Swissprot database search at NCBI
Blast PDB database search at NCBI
Blast NR database search at NCBI
Asp f 2 - Statistics from Alphafold ( SI is sequence id, Best template format: PDB_ChainID)
Allergen Name pLDDT Score pTM Score Best PDB template %Seq ID Align length Seq length Query Range Sequence Range E-Value Bit Score Download Model
Asp f 2 82.7 0.66 3NWL_A 25.806 62 310 126 - 186 206 - 267 3.1 30.8 Download (SI: 39)
Asp f 2 - Alphafold Theoretical Model Structure
Model Structure
39_relaxed_rank_1_model_2.pdb


Coverage Plddt
Asp f 2 - Protein Sequence Properties!
Protein Sequence Protease cleavage sites PeptideCutter at ExPASy
P79017 Click here to process the data
Asp f 2 - PFAM Information
SeqID Aller ID AlnS AlnE EnvS EnvE PFAM ID Family Type Clan Description
39 150 29 249 5 249 PF13933 HRXXH Domain CL0126 Putative peptidase family
Where: AlnS= Alignment start position, AlnE= Alignment end position, EnvS= Envelope start position, EnvE= Envelope end position.

List of B-cell epitopes predicted by BepiPred method using a window size of 9 amino acids

Cleck here for epitopes predicted by BepiPred method
Asp f 2 - Epitope Information from published data
No. Position Epitope Sequence Epitope Type View epitope Search epitope in SDAP PD search in SDAP Cross-React search
1 58-64 ATQRRQI IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
2 93-97 RKYFG IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
3 138-140 HWR IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
4 155-159 YTTRR IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
5 181-185 ASDLM IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
6 189-192 YHVP IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
7 200-204 DHFAD IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
8 231-236 ALEAYA IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
9 301-306 THEGGQ IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
39_relaxed_rank_1_model_2.pdb



Epitope Reference ( ID 8): B. Banerjee, P. A. Greenberger, J. N. Fink, and V. P. Kurup, Conformational and linear B-cell epitopes of Asp f 2, a major allergen of Aspergillus fumigatus, bind differently to immunoglobulin E antibody in the sera of allergic bronchopulmonary aspergillosis patients, Infect. Immun. 1999, 67, 2284-2291.
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