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                SDAP 2.0 - Structural Database of Allergenic Proteins
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Werner Braun      Submit new allergen information to SDAP
  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Access to SDAP is available free of charge for Academic and non-profit use.< Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu). Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen Info Description
Allergen ID 42
Allergen Scientific Name Bet v 2
Allergen Species - Systematic Name Betula verrucosa (Betula pendula)
Allergen Species - Common Name White birch
Allergen Common source tree
Allergen Common name Fagales
Allergen Keywords profilin
Allergen IUIS (Yes=1, No=0) 1
ID Allergen Name
Bet v 2 - References
ID Reference
Pubmed ID: 9802365
Niederberger V, Pauli G, Gronlund H, Froschl R, Rumpold H, Kraft D, Valenta R, Spitzauer S. Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations. J Allergy Clin Immunol. 1998 Oct;102(4 Pt 1):579-91.
Pubmed ID: 1857985
Valenta R, Duchene M, Pettenburger K, Sillaber C, Valent P, Bettelheim P, Breitenbach M, Rumpold H, Kraft D, Scheiner O. Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals. Science. 1991 Aug 2;253(5019):557-60.
Pubmed ID: 9016715
Fedorov AA, Ball T, Mahoney NM, Valenta R, Almo SC. The molecular basis for allergen cross-reactivity: crystal structure and IgE-epitope mapping of birch pollen profilin. Structure. 1997 Jan 15;5(1):33-45.
Pubmed ID: 9130496
Fedorov AA, Ball T, Valenta R, Almo SC. X-ray crystal structures of birch pollen profilin and Phl p 2. Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):109-13.
Pubmed ID: 9271223
Domke T, Federau T, Schluter K, Giehl K, Valenta R, Schomburg D, Jockusch BM. Birch pollen profilin: structural organization and interaction with poly-(L-proline) peptides as revealed by NMR. FEBS Lett. 1997 Jul 14;411(2-3):291-5.
Bet v 2 - Protein Sequences
Source Link to source
SwissProt P25816
Bet v 2 - PDB Structure
PDB Id PDB Name PDB Entry Deposition Date Experiment Type Observation
42 154 1CQA 26-JUL-96 X-ray diffraction resolution 2.4 A
1CQA.pdb


Bet v 2 - Sequence Search :
Sequence Header Sequence
Bet v 2
SDAP Sequence ID: 59
SDAP Allergen ID: 42
MSWQTYVDEHLMCDIDGQASNSLASAIVGHDGSVWAQSSSFPQFKPQEITGIMKDFEEPGHLAPTGLHLGGIKYMVIQGEAGAVIRGKKGSGGITIKKTGQALVFGIYEEPVTPGQCNMVVERLGDYLIDQGL
View 3D Structure Click here to view 3D model structure of allergen
Fasta Search in SDAP
Blast Swissprot database search at NCBI
Blast PDB database search at NCBI
Blast NR database search at NCBI
Bet v 2 - Statistics from Alphafold ( SI is sequence id, Best template format: PDB_ChainID)
Allergen Name pLDDT Score pTM Score Best PDB template %Seq ID Align length Seq length Query Range Sequence Range E-Value Bit Score Download Model
Bet v 2 90.05 0.83 1CQA_A 96.241 133 133 1 - 133 1 - 133 0 263 Download (SI: 59)
Bet v 2 - Alphafold Theoretical Model Structure
Model Structure
59_relaxed_rank_1_model_2.pdb


Coverage Plddt
Bet v 2 - Protein Sequence Properties!
Protein Sequence Protease cleavage sites PeptideCutter at ExPASy
P25816 Click here to process the data
Bet v 2 - PFAM Information
SeqID Aller ID AlnS AlnE EnvS EnvE PFAM ID Family Type Clan Description
59 42 1 132 1 133 PF00235 Profilin Domain CL0431 Profilin
Where: AlnS= Alignment start position, AlnE= Alignment end position, EnvS= Envelope start position, EnvE= Envelope end position.

List of B-cell epitopes predicted by BepiPred method using a window size of 9 amino acids

Cleck here for epitopes predicted by BepiPred method
Bet v 2 - Epitope Information from published data
No. Position Epitope Sequence Epitope Type View epitope Search epitope in SDAP PD search in SDAP Cross-React search
No epitope information found!
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