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Department of Biochemistry and Molecular Biology Sealy Center for Structural Biology Computational Biology



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                SDAP 2.0 - Structural Database of Allergenic Proteins
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Werner Braun      Submit new allergen information to SDAP
  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Access to SDAP is available free of charge for Academic and non-profit use.< Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu). Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen Info Description
Allergen ID 305
Allergen Scientific Name Mal d 2
Allergen Species - Systematic Name Malus domestica
Allergen Species - Common Name apple
Allergen Common source foods
Allergen Common name
Allergen Keywords homolog: thaumatin; homolog: pathogenesis related protein PR5
Allergen IUIS (Yes=1, No=0) 1
ID Allergen Name
Mal d 2 - References
ID Reference
Pubmed ID: 12787673
Krebitz M, Wagner B, Ferreira F, Peterbauer C, Campillo N, Witty M, Kolarich D, Steinkellner H, Scheiner O, Breiteneder H, Plant-based heterologous expression of Mal d 2, a thaumatin-like protein and allergen of apple (Malus domestica), and its characterization as an antifungal protein. J Mol Biol. 2003 Jun 13;329(4):721-30.
Pubmed ID: 14705920
Ivanciuc O, Mathura V, Midoro-Horiuti T, Braun W, Goldblum RM, Schein CH, Detecting potential IgE-reactive sites on food proteins using a sequence and structure database, SDAP-food. J Agric Food Chem. 2003 Jul 30;51(16):4830-7.
Mal d 2 - Protein Sequences
Source Link to source
GenBank 10334651
Mal d 2 - PDB Structure
PDB Id PDB Name PDB Entry Deposition Date Experiment Type Observation
305 305 3ZS3 2011-06-22 X-ray diffraction resolution 1.80 A high resolution structure of Mal D 2, the thaumatin-like food allergen from apple
3ZS3.pdb


Mal d 2 - Theoretical Model Structure
Model ID PDB file PDB Snapshot PDB Snapshot 90 PDB Snapshot 180 PDB Snapshot 270 3D PDB View
280 GetModel Model Pic Model Pic Model Pic Model Pic Click here
Mal d 2 - Sequence Search :
Sequence Header Sequence
Mal d 2
SDAP Sequence ID: 280
SDAP Allergen ID: 305
MMKSQVASLLGLTLAILFFSGAHAAKITFTNNCPNTVWPGTLTGDQKPQLSLTGFELASKASRSVDAPSPWSGRFWGRTRCSTDAAGKFTCETADCGSGQVACNGAGAVPPATLVEITIAANGGQDYYDVSLVDGFNLPMSVAPQGGTGECKPSSCPANVNKVCPAPLQVKAADGSVISCKSACLAFGDSKYCCTPPNNTPETCPPTEYSEIFEKQCPQAYSYAYDDKNSTFTCSGGPDYVITFCP
View 3D Structure Click here to view 3D model structure of allergen
Fasta Search in SDAP
Blast Swissprot database search at NCBI
Blast PDB database search at NCBI
Blast NR database search at NCBI
Mal d 2 - Statistics from Alphafold ( SI is sequence id, Best template format: PDB_ChainID)
Allergen Name pLDDT Score pTM Score Best PDB template %Seq ID Align length Seq length Query Range Sequence Range E-Value Bit Score Download Model
Mal d 2 93.05 0.81 3ZS3_A 100 222 246 25 - 246 1 - 222 0 453 Download (SI: 280)
Mal d 2 - Alphafold Theoretical Model Structure
Model Structure
280_relaxed_rank_1_model_4.pdb


Coverage Plddt
Mal d 2 - Protein Sequence Properties!
Protein Sequence Protease cleavage sites PeptideCutter at ExPASy
10334651 Click here to process the data
Mal d 2 - PFAM Information
SeqID Aller ID AlnS AlnE EnvS EnvE PFAM ID Family Type Clan Description
280 305 31 246 31 246 PF00314 Thaumatin Domain CL0293 Thaumatin family
Where: AlnS= Alignment start position, AlnE= Alignment end position, EnvS= Envelope start position, EnvE= Envelope end position.

List of B-cell epitopes predicted by BepiPred method using a window size of 9 amino acids

Cleck here for epitopes predicted by BepiPred method
Mal d 2 - Epitope Information from published data
No. Position Epitope Sequence Epitope Type View epitope Search epitope in SDAP PD search in SDAP Cross-React search
No epitope information found!
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