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Department of Biochemistry and Molecular Biology Sealy Center for Structural Biology Computational Biology


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                SDAP 2.0 - Structural Database of Allergenic Proteins
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Werner Braun      Submit new allergen information to SDAP
  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Access to SDAP is available free of charge for Academic and non-profit use.< Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu). Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen Info Description
Allergen ID 283
Allergen Scientific Name Pen a 1
Allergen Species - Systematic Name Penaeus aztecus
Allergen Species - Common Name shrimp
Allergen Common source foods
Allergen Common name
Allergen Keywords tropomyosin
Allergen IUIS (Yes=1, No=0) 1
ID Allergen Name
Pen a 1 - References
ID Reference
Pubmed ID: 15672477
DeWitt AM, Mattsson L, Lauer I, Reese G, Lidholm J, Recombinant tropomyosin from Penaeus aztecus (rPen a 1) for measurement of specific immunoglobulin E antibodies relevant in food allergy to crustaceans and other invertebrates. Mol Nutr Food Res. 2004 Oct;48(5):370-9.
Pubmed ID: 11893851
Ayuso R, Lehrer SB, Reese G, Identification of continuous, allergenic regions of the major shrimp allergen Pen a 1 (tropomyosin). Int Arch Allergy Immunol. 2002 Jan;127(1):27-37.
Pubmed ID: 10224419
Reese G, Ayuso R, Carle T, Lehrer SB, IgE-binding epitopes of shrimp tropomyosin, the major allergen Pen a 1. Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):300-1.
Pen a 1 - Protein Sequences
Source Link to source
GenBank 11893851
Pen a 1 - Theoretical Model Structure
Model ID PDB file PDB Snapshot PDB Snapshot 90 PDB Snapshot 180 PDB Snapshot 270 3D PDB View
284 GetModel Model Pic Model Pic Model Pic Model Pic Click here
Pen a 1 - Sequence Search :
Sequence Header Sequence
Pen a 1
SDAP Sequence ID: 284
SDAP Allergen ID: 283
MDAIKKKMQAMKLEKDNAMDRADTLEQQNKEANNRAEKSEEEVHNLQKRMQQLENDLDQVQESLLKANIQLVEKDKALSNAEGEVAALNRRIQLLEEDLERSEERLNTATTKLAEASQAADESERMRKVLENRSLSDEERMDALENQLKEARFLAEEADRKYDEVARKLAMVEADLERAEERAETGESKIVELEEELRVVGNNLKSLEVSEEKANQREEAYKEQIKTLTNKLKAAEARAEFAERSVQKLQKEVDRLEDELVNEKEKYKSITDELDQTFSELSGY
View 3D Structure Click here to view 3D model structure of allergen
Fasta Search in SDAP
Blast Swissprot database search at NCBI
Blast PDB database search at NCBI
Blast NR database search at NCBI
Pen a 1 - Statistics from Alphafold ( SI is sequence id, Best template format: PDB_ChainID)
Allergen Name pLDDT Score pTM Score Best PDB template %Seq ID Align length Seq length Query Range Sequence Range E-Value Bit Score Download Model
Pen a 1 90.9 0.38 1C1G_A 56.184 283 284 1 - 283 1 - 283 0 282 Download (SI: 284)
Pen a 1 - Alphafold Theoretical Model Structure
Model Structure
284_relaxed_rank_1_model_5.pdb


Coverage Plddt
Pen a 1 - Protein Sequence Properties!
Protein Sequence Protease cleavage sites PeptideCutter at ExPASy
11893851 Click here to process the data
Pen a 1 - PFAM Information
SeqID Aller ID AlnS AlnE EnvS EnvE PFAM ID Family Type Clan Description
284 283 57 283 57 284 PF00261 Tropomyosin Coiled-coil CL0452 Tropomyosin
Where: AlnS= Alignment start position, AlnE= Alignment end position, EnvS= Envelope start position, EnvE= Envelope end position.

List of B-cell epitopes predicted by BepiPred method using a window size of 9 amino acids

Cleck here for epitopes predicted by BepiPred method
Pen a 1 - Epitope Information from published data
No. Position Epitope Sequence Epitope Type View epitope Search epitope in SDAP PD search in SDAP Cross-React search
1 43-57 VHNLQKRMQQLENDL IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
2 85-99 VAALNRRIQLLEEDL IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
3 91-105 RIQLLEEDLERSEER IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
4 133-147 RSLSDEERMDALENQ IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
5 187-201 ESKIVELEEELRVVG IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
6 247-261 QKLQKEVDRLEDELV IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
7 253-267 VDRLEDELVNEKEKY IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
8 259-273 ELVNEKEKYKSITDE IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
9 265-279 EKYKSITDELDQTFS IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
284_relaxed_rank_1_model_5.pdb



Epitope Reference ( ID 19): R. Ayuso, S. B. Lehrer, and G. Reese, Identification of continuous, allergenic regions of the major shrimp allergen Pen a 1 (tropomyosin), Int. Arch. Allergy Immunol. 2002, 127, 27-37.
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