The University of Texas Medical Branch
Department of Biochemistry and Molecular Biology Sealy Center for Structural Biology Computational Biology

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SDAP - All Allergens
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Ovidiu Ivanciuc      Submit new allergen information to SDAP
Last Updated: February 25, 2013  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Access to SDAP is available free of charge for Academic and non-profit use.
Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu).
Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen Bet v 1

Translate to AllerML
AllergenBet v 1
Typetree
Species - Systematic NameFagales; Betula verrucosa (Betula pendula)
Species - Common NameWhite birch
Keywordshomolog: pathogenesis related protein PR10
ClassIUIS

Bet v 1 - PubMedReference
Reference 1Breiteneder H, Pettenburger K, Bito A, Valenta R, Kraft D, Rumpold H, Scheiner O, Breitenbach M. The gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene. EMBO J. 1989 Jul;8(7):1935-8.
Reference 2Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD. X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy. Nat Struct Biol. 1996 Dec;3(12):1040-5.
Reference 3Valenta R, Breiteneder H, Petternburger K, Breitenbach M, Rumpold H, Kraft D, Scheiner O. Homology of the major birch-pollen allergen, Bet v I, with the major pollen allergens of alder, hazel, and hornbeam at the nucleic acid level as determined by cross-hybridization. J Allergy Clin Immunol. 1991 Mar;87(3):677-82.
Reference 4Spangfort MD, Mirza O, Ipsen H, Van Neerven RJ, Gajhede M, Larsen JN. Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis. J Immunol. 2003 Sep 15;171(6):3084-90.
Reference 5Markovic-Housley Z, Degano M, Lamba D, von Roepenack-Lahaye E, Clemens S, Susani M, Ferreira F, Scheiner O, Breiteneder H. Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier. J Mol Biol. 2003 Jan 3;325(1):123-33.
Reference 6Ebner C, Szepfalusi Z, Ferreira F, Jilek A, Valenta R, Parronchi P, Maggi E, Romagnani S, Scheiner O, Kraft D. Identification of multiple T cell epitopes on Bet v I, the major birch pollen allergen, using specific T cell clones and overlapping peptides. J Immunol. 1993 Feb 1;150(3):1047-54.
Reference 7Sparholt SH, Larsen JN, Ipsen H, Schou C, van Neerven RJ. Crossreactivity and T-cell epitope specificity of Bet v 1-specific T cells suggest the involvement of multiple isoallergens in sensitization to birch pollen. Clin Exp Allergy. 1997 Aug;27(8):932-41.
Reference 8Niederberger V, Pauli G, Gronlund H, Froschl R, Rumpold H, Kraft D, Valenta R, Spitzauer S. Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations. J Allergy Clin Immunol. 1998 Oct;102(4 Pt 1):579-91.

Bet v 1 - Isoallergens
NoIsoallergen
1Bet v 1.0101
2Bet v 1.0102
3Bet v 1.0103
4Bet v 1.0201
5Bet v 1.0301
6Bet v 1.0401
7Bet v 1.0402
8Bet v 1.0501
9Bet v 1.0601
10Bet v 1.0602
11Bet v 1.0701
12Bet v 1.0801
13Bet v 1.0901
14Bet v 1.1001
15Bet v 1.1101
16Bet v 1.1201
17Bet v 1.1301
18Bet v 1.1401
19Bet v 1.1402
20Bet v 1.1501
21Bet v 1.1502
22Bet v 1.1601
23Bet v 1.1701
24Bet v 1.1801
25Bet v 1.1901
26Bet v 1.2001
27Bet v 1.2101
28Bet v 1.2201
29Bet v 1.2301
30Bet v 1.2401
31Bet v 1.2501
32Bet v 1.2601
33Bet v 1.2701
34Bet v 1.2801
35Bet v 1.2901
36Bet v 1.3001
37Bet v 1.3101
38Bet v 1.at10
39Bet v 1.at14
40Bet v 1.at21
41Bet v 1.at37
42Bet v 1.at42
43Bet v 1.at45
44Bet v 1.at5
45Bet v 1.at50
46Bet v 1.at59
47Bet v 1.at7
48Bet v 1.at8
49Bet v 1.at87
50Bet v 1.jap1
51Bet v 1.jap2
52Bet v 1.jap3

Bet v 1 - Protein Sequences
SourceLink to SourceView SequenceFASTA@SDAPBLAST@NCBIBLAST@ExPASyPROSITE@PIR
SwissProtP45431Go!Go!Go!Go!Go!
SwissProtP43176Go!Go!Go!Go!Go!
SwissProtP43178Go!Go!Go!Go!Go!
SwissProtP43180Go!Go!Go!Go!Go!
SwissProtP43183Go!Go!Go!Go!Go!
SwissProtP43184Go!Go!Go!Go!Go!
SwissProtP43185Go!Go!Go!Go!Go!
GenBank2564226Go!Go!Go!Go!Go!
GenBank2564220Go!Go!Go!Go!Go!
GenBank2564224Go!Go!Go!Go!Go!
GenBank2564228Go!Go!Go!Go!Go!
FASTA@SDAP: FASTA search against all SDAP allergen sequences performed at SDAP
BLAST@ExPASy: BLAST search performed at the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)
PROSITE@PIR: PROSITE search performed at PIR - Protein Information Resources

Bet v 1 - Protein Sequence Properties
Protein SequenceProtease cleavage sites
PeptideCutter@ExPASy
P45431Go!
P43176Go!
P43178Go!
P43180Go!
P43183Go!
P43184Go!
P43185Go!
2564226Go!
2564220Go!
2564224Go!
2564228Go!
PeptideCutter@ExPASy: Protease cleavage sites predicted with PeptideCutter from the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)

Bet v 1 - Protein Similarity, Classification and Clustering
Protein SequenceSuperfamilyInterPro
P45431Go!Go!
P43176Go!Go!
P43178Go!Go!
P43180Go!Go!
P43183Go!Go!
P43184Go!Go!
P43185Go!Go!

Bet v 1 - PDB Structures
PDB AccessionJmolDeposition dateExperimentalObservation
1BTVView!30-JAN-97NMR, 20 structures 
1BV1View!08-JUL-97X-ray diffraction resolution 2.0 A 
1B6FView!13-JAN-99NMR, 23 structuresmutant
1FSKView!11-SEP-00X-ray diffraction resolution 2.9 Acomplex with IgG Ab Fab
1QMRView!06-OCT-99X-ray diffraction resolution 2.15 Amutant
3K78View!2009-10-12X-ray diffraction resolution 2.80 A 
1FM4View!2000-08-16X-ray diffraction resolution 1.97 ABet v 1l is a naturally occurring hypoallergenic isoform of Bet v 1
1LLTView!2002-04-30X-ray diffraction resolution 3.10 AE45S mutant

Bet v 1 - Epitopes
NoEpitopeExact
Match
@SDAP
Peptide
Similarity
@SDAP
Exact
Match
@PIR
PositionTypeDescription
1E42N43I44E45G46N47G48G49P50G51T52R70D72H76I86K97Go!Go!Go!42-97IgE 
M. D. Spangfort, O. Mirza, H. Ipsen, R. J. Van Neerven, M. Gajhede, and J. N. Larsen, Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis. J. Immunol. 2003, 171, 3084-3090.


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