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SDAP - All Allergens
| | Allergen Bet v 1Translate to AllerML | | | | | Allergen | Bet v 1 | | Type | tree | | Species - Systematic Name | Fagales; Betula verrucosa (Betula pendula) | | Species - Common Name | White birch | | Keywords | homolog: pathogenesis related protein PR10
| | Class | IUIS |
| |
| Bet v 1 - PubMed | Reference | | Reference 1 | Breiteneder H, Pettenburger K, Bito A, Valenta R, Kraft D, Rumpold H, Scheiner O, Breitenbach M. The gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene. EMBO J. 1989 Jul;8(7):1935-8. | | Reference 2 | Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD. X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy. Nat Struct Biol. 1996 Dec;3(12):1040-5. | | Reference 3 | Valenta R, Breiteneder H, Petternburger K, Breitenbach M, Rumpold H, Kraft D, Scheiner O. Homology of the major birch-pollen allergen, Bet v I, with the major pollen allergens of alder, hazel, and hornbeam at the nucleic acid level as determined by cross-hybridization. J Allergy Clin Immunol. 1991 Mar;87(3):677-82. | | Reference 4 | Spangfort MD, Mirza O, Ipsen H, Van Neerven RJ, Gajhede M, Larsen JN. Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis. J Immunol. 2003 Sep 15;171(6):3084-90. | | Reference 5 | Markovic-Housley Z, Degano M, Lamba D, von Roepenack-Lahaye E, Clemens S, Susani M, Ferreira F, Scheiner O, Breiteneder H. Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier. J Mol Biol. 2003 Jan 3;325(1):123-33. | | Reference 6 | Ebner C, Szepfalusi Z, Ferreira F, Jilek A, Valenta R, Parronchi P, Maggi E, Romagnani S, Scheiner O, Kraft D. Identification of multiple T cell epitopes on Bet v I, the major birch pollen allergen, using specific T cell clones and overlapping peptides. J Immunol. 1993 Feb 1;150(3):1047-54. | | Reference 7 | Sparholt SH, Larsen JN, Ipsen H, Schou C, van Neerven RJ. Crossreactivity and T-cell epitope specificity of Bet v 1-specific T cells suggest the involvement of multiple isoallergens in sensitization to birch pollen. Clin Exp Allergy. 1997 Aug;27(8):932-41. | | Reference 8 | Niederberger V, Pauli G, Gronlund H, Froschl R, Rumpold H, Kraft D, Valenta R, Spitzauer S. Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations. J Allergy Clin Immunol. 1998 Oct;102(4 Pt 1):579-91. |
Bet v 1 - Isoallergens
Bet v 1 - Protein Sequences
FASTA@SDAP: FASTA search against all SDAP allergen sequences performed at SDAP
BLAST@ExPASy: BLAST search performed at the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)
PROSITE@PIR: PROSITE search performed at PIR - Protein Information Resources
Bet v 1 - Protein Sequence Properties
PeptideCutter@ExPASy: Protease cleavage sites predicted with PeptideCutter from the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)
Bet v 1 - Protein Similarity, Classification and Clustering
Bet v 1 - PDB Structures
| PDB Accession | Jmol | Deposition date | Experimental | Observation | | 1BTV | View! | 30-JAN-97 | NMR, 20 structures | | | 1BV1 | View! | 08-JUL-97 | X-ray diffraction resolution 2.0 A | | | 1B6F | View! | 13-JAN-99 | NMR, 23 structures | mutant | | 1FSK | View! | 11-SEP-00 | X-ray diffraction resolution 2.9 A | complex with IgG Ab Fab | | 1QMR | View! | 06-OCT-99 | X-ray diffraction resolution 2.15 A | mutant | | 3K78 | View! | 2009-10-12 | X-ray diffraction resolution 2.80 A | | | 1FM4 | View! | 2000-08-16 | X-ray diffraction resolution 1.97 A | Bet v 1l is a naturally occurring hypoallergenic isoform of Bet v 1 | | 1LLT | View! | 2002-04-30 | X-ray diffraction resolution 3.10 A | E45S mutant |
Bet v 1 - Epitopes| No | Epitope | Exact
Match
@SDAP | Peptide
Similarity
@SDAP | Exact
Match
@PIR | Position | Type | Description | | 1 | E42N43I44E45G46N47G48G49P50G51T52R70D72H76I86K97 | Go! | Go! | Go! | 42-97 | IgE |
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M. D. Spangfort, O. Mirza, H. Ipsen, R. J. Van Neerven, M. Gajhede, and J. N. Larsen,
Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen,
characterized by X-ray crystallography and site-directed mutagenesis.
J. Immunol. 2003, 171, 3084-3090.
|
