|Department of Biochemistry and Molecular Biology||Sealy Center for Structural Biology||Computational Biology|
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SDAP 2.0 - Structural Database of Allergenic Proteins
Structural Biology of Allergens
Structural Database of Allergenic Proteins
SDAP (Structural Database of Allergenic Proteins) is a Web server that provides database information and various cobputational tools for the study of allergenic proteins. The database component of SDAP contains information the allergen name, source, sequence, structure, IgE epitopes, and literature references, and links to the major protein (PDB, SWISS-PROT, PIR, GenBank) and literature (PubMed, MEDLINE) servers. The computational component in SDAP uses an original algorithm based on conserved properties of amino acid side chains to identify regions of known allergens similar to user-supplied peptides or selected from the SDAP database of IgE epitopes. This and other bioinformatics tools can be used to rapidly determine potential cross-reactivities between allergens and to screen novel proteins for the presence of IgE epitopes they may share with known allergens.
Criteria for Allergen Addition to SDAP
The SDAP database contains all allergens from the IUIS (International Union of Immunological Societies) website, http://www.allergen.org, supplemented with information from literature and from major sequence (SwissProt, PIR, and NCBI) and structure (PDB) databases.
The major SDAP source of allergens is the IUIS list, http://www.allergen.org, supplemented with literature and database information on proteins considered allergens by the authors of the respective communication. For each protein in the SDAP database we indicate if it is an IUIS or non-IUIS allergen. The user can select the group of allergens used for searching the SDAP database: (a) IUIS allergens; (b) IUIS and non-IUIS allergens.
SDAP is updated each three months (at the end of March, June, September, and December). An archive containing the SDAP status before each update (containing allergen names and sequence accession numbers) is available as a reference for interested users.