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SDAP - All Allergens
| | Allergen Api m 1Translate to AllerML | | | | | Allergen | Api m 1 | | Type | insects | | Species - Systematic Name | Apis mellifera | | Species - Common Name | honey bee | | Keywords | phospholipase A2; Phosphatidylcholine 2-acylhydrolase; EC 3.1.1.4
| | Class | IUIS |
| |
| Api m 1 - PubMed | Reference | | Reference 1 | Weber A, Schroder H, Thalberg K, Marz L, Specific interaction of IgE antibodies with a carbohydrate epitope of honey bee venom phospholipase A2. Allergy. 1987 Aug;42(6):464-70. | | Reference 2 | Blaser K, Carballido J, Faith A, Crameri R, Akdis C, Determinants and mechanisms of human immune responses to bee venom phospholipase A2. Int Arch Allergy Immunol. 1998 Sep;117(1):1-10. | | Reference 3 | Muller U, Akdis CA, Fricker M, Akdis M, Blesken T, Bettens F, Blaser K, Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):747-54. | | Reference 4 | Carballido JM, Carballido-Perrig N, Kagi MK, Meloen RH, Wuthrich B, Heusser CH, Blaser K, T cell epitope specificity in human allergic and nonallergic subjects to bee venom phospholipase A2. J Immunol. 1993 Apr 15;150(8 Pt 1):3582-91. | | Reference 5 | Kuchler K, Gmachl M, Sippl MJ, Kreil G, Analysis of the cDNA for phospholipase A2 from honeybee venom glands. The deduced amino acid sequence reveals homology to the corresponding vertebrate enzymes. Eur J Biochem. 1989 Sep 1;184(1):249-54. | | Reference 6 | Buhot C, Chenal A, Sanson A, Pouvelle-Moratille S, Gelb MH, Menez A, Gillet Alteration of the tertiary structure of the major bee venom allergen Api m 1 by multiple mutations is concomitant with low IgE reactivity. Protein Sci. 2004 Nov;13(11):2970-8. Epub 2004 Sep 30. |
Api m 1 - Protein Sequences
| Source | Link to Source | View Sequence | FASTA@SDAP | BLAST@NCBI | BLAST@ExPASy | PROSITE@PIR | | SwissProt | P00630 | Go! | Go! | Go! | Go! | Go! |
FASTA@SDAP: FASTA search against all SDAP allergen sequences performed at SDAP
BLAST@ExPASy: BLAST search performed at the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)
PROSITE@PIR: PROSITE search performed at PIR - Protein Information Resources
Api m 1 - Protein Sequence Properties
| Protein Sequence | Protease cleavage sites
PeptideCutter@ExPASy | | P00630 | Go! | |
PeptideCutter@ExPASy: Protease cleavage sites predicted with PeptideCutter from the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)
Api m 1 - Protein Similarity, Classification and Clustering
Api m 1 - PDB Structures
| PDB Accession | Jmol | Deposition date | Experimental | Observation | | 1POC | View! | 07-SEP-92 | X-ray diffraction resolution 2.0 A | complex with transition-state analogue |
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