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                SDAP - Structural Database of Allergenic Proteins
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Werner Braun      Submit new allergen information to SDAP
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Access to SDAP is available free of charge for Academic and non-profit use.
Licenses for commercial use can be obtained by contacting W. Braun (
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Allergen Info Description
Allergen ID 132
Allergen Scientific Name Alt a 1
Allergen Species - Systematic Name Alternaria alternata
Allergen Species - Common Name
Allergen Common source fungi (moulds)
Allergen Common name Ascomycota Dothidiales
Allergen Keywords N
Allergen IUIS (Yes=1, No=0) 1

Alt a 1 : There are iso allergen in the table! Click on each allergen for more information.

ID Allergen Name
1 Alt a 1.0101
2 Alt a 1.0102
Alt a 1 - References
ID Reference
Pubmed ID: 12668200
Kurup VP, Vijay HM, Kumar V, Castillo L, Elms N, IgE binding synthetic peptides of Alt a 1, a major allergen of Alternaria alternata. Peptides. 2003 Feb;24(2):179-85.
Pubmed ID: 9647269
Rosenthal D, Hu F, Pacheco F, Landuyt J, Barnes C, Portnoy J, Northern blot identification of mRNA containing sequence for protein allergen, Alt a1, in eight strains of Alternaria alternata. Ann Allergy Asthma Immunol. 1998 Jun;80(6):471-5.
Pubmed ID: 8957113
De Vouge MW, Thaker AJ, Curran IH, Zhang L, Muradia G, Rode H, Vijay HM, Isolation and expression of a cDNA clone encoding an Alternaria alternata Alt a 1 subunit. Int Arch Allergy Immunol. 1996 Dec;111(4):385-95.
Pubmed ID: 7580290
Zhang L, Curran IH, Muradia G, De Vouge MW, Rode H, Vijay HM, N-terminus of a major allergen, Alt a I, of Alternaria alternata defined to be an epitope. Int Arch Allergy Immunol. 1995 Nov;108(3):254-9.
Alt a 1 - Protein Sequences
Source Link to source
SwissProt P79085
Alt a 1 - PDB Structure
PDB Id PDB Name PDB Entry Deposition Date Experiment Type Observation
132 306 3V0R 2011-12-08 X-ray diffraction resolution 1.90 A crystal structure of Alternaria alternata allergen Alt a 1

Alt a 1 - Sequence Search
Sequence Header Sequence
Alt a 1
SDAP Sequence ID: 8
SDAP Allergen ID: 132
View 3D Structure Click here to view 3D model structure of allergen
Fasta Search in SDAP
Blast Swissprot database search at NCBI
Blast PDB database search at NCBI
Blast NR database search at NCBI
Expasy Blast Search
Alt a 1 - Statistics from Alphafold ( SI is sequence id, Best template format: PDB_ChainID)
Allergen Name pLDDT Score pTM Score Best PDB template %Seq ID Align length Seq length Query Range Sequence Range E-Value Bit Score Download Model
Alt a 1 87.4 0.7 3V0R_A 99.248 133 157 25 - 157 1 - 133 0 278 Download (SI: 8)
Alt a 1 - Alphafold Theoretical Model Structure
Model Structure

Coverage Plddt
Alt a 1 - Protein Sequence Properties!
Protein Sequence Protease cleavage sites PeptideCutter at ExPASy
P79085 Click here to process the data
Alt a 1 - PFAM Information
SeqID Aller ID AlnS AlnE EnvS EnvE PFAM ID Family Type Clan Description
8 132 42 140 42 140 PF16541 AltA1 Domain No_clan Alternaria alternata allergen 1
Where: AlnS= Alignment start position, AlnE= Alignment end position, EnvS= Envelope start position, EnvE= Envelope end position.


Predicted B-Cell epitope using BCEP method for Alt a 1

Probe radius : 1.400

POLAR area/energy = 4261.33

APOLAR area/energy = 7254.45

Total area/energy = 11515.78

Number of surface atoms = 806

Number of buried atoms = 388

Residues Predicted with high probability (in top five patches) are: 1,2,134,135,136,131,132,133,81,82,83,84,85,86,87 , and medium probability (next top five patches) are : 87,54,80,88,96,109,100,37,38,39,66,93,110,111,50 . Predicted residues are shown in red and green color stick representation.

Original PDB file 4434.test.pdb
Original PDB file with surface residue only. All amino acid residue are replaced by their CB atom, in case of GLY CA atom is used. Solvent accessible surface area of each residue is stored in last column of the PDB file. 14434.test.txt
Patch drawn around the residues by patch analysis are stored in this file
How to read: Col 1: Patch No. Col 2: Center Res Name. Col 3: Sum(Pint*Area), Col 4: Sum(Psur*Area), Col 5: Total Residue, Col 6: Interface score, Col 7: Surface Score, Col 8: Max Interface Score, Col 9: Minimum Interface Score
Residues predicted by patch analysis are stored in this file.
How to read: Col 1: Patch No. Col 2: Center Res Name. Col 3: Res Number Col 4: Neigbouring Res Name, Col 5: Sum(Pint*Area). Col 6: Sum(PSur*Area), Col 7: Sum(Area), Col 8: Similar no of residue in patch (e.g CYS, CYS = 2)
All residues scored by patch analysis are stored in this file.
How to read: Col 1: Patch No. Col 2: Center Res Name. Col 3: Sum(Pint*Area)/sum(Area), Col 4: Sum(Psur*Area)/sum(Area), Col 5: Total Residue

[For BCEP predicted results, please cite our websites for your future publications (Negi et al., Bioinformatics, 23, 3397-3399, 2007 , Negi et al., J. Mol. Model., 13, 1157-1167, 2007; Negi et al., J. Mol. Model., 12, 921-929, 2006)]

List of B-cell epitopes predicted by BepiPred method using a window size of 9 amino acids
Peptides predicted from BepiPred method can be used to search related peptides in SDAP using PD search and Cross-React method.
Please note: BepiPred Epitopes are predicted using BepiPred webserver implemented in IEDB Analysis Resource at
Cleck here for epitopes predicted by BepiPred method

Alt a 1 - Epitope Information from published data
No. Position Epitope Sequence Epitope Type View epitope Search epitope in SDAP PD search in SDAP Cross-React search
1 41-50 KISEFYGRKP IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
2 54-63 YYNSLGFNIK IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search

Epitope Reference ( ID 20): V. P. Kurup, H. M. Vijay, V. Kumar, L. Castillo, and N. Elms, IgE binding synthetic peptides of Alt a 1, a major allergen of Alternaria alternata, Peptides 2003, 00, 00-00.
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