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Department of Biochemistry and Molecular Biology Sealy Center for Structural Biology Computational Biology



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                SDAP 2.0 - Structural Database of Allergenic Proteins
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Werner Braun      Submit new allergen information to SDAP
  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Access to SDAP is available free of charge for Academic and non-profit use.< Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu). Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen Info Description
Allergen ID 774
Allergen Scientific Name Ana c 2
Allergen Species - Systematic Name Ananas comosus
Allergen Species - Common Name pineapple
Allergen Common source foods
Allergen Common name
Allergen Keywords bromelain
Allergen IUIS (Yes=1, No=0) 1
ID Allergen Name
Ana c 2 - References
ID Reference
Pubmed ID: 627040
Clin Allergy. 1978 Jan;8(1):21-4. Galleguillos F, Rodriguez JC, Asthma caused by bromelin inhalation.
Pubmed ID: 3233722
Gailhofer G, Wilders-Truschnig M, Smolle J, Ludvan M, Asthma caused by bromelain: an occupational allergy. Clin Allergy. 1988 Sep;18(5):445-50.
Pubmed ID: 498487
Baur X, Studies on the specificity of human IgE-antibodies to the plant proteases papain and bromelain. Clin Allergy. 1979 Sep;9(5):451-7.
Pubmed ID: 498486
Baur X, Fruhmann G Allergic reactions, including asthma, to the pineapple protease bromelain following occupational exposure. Clin Allergy. 1979 Sep;9(5):443-50.
Ana c 2 - Protein Sequences
Source Link to source
GenBank 2342496
Ana c 2 - Sequence Search :
Sequence Header Sequence
Ana c 2
SDAP Sequence ID: 859
SDAP Allergen ID: 774
MASKVQLVFLFLFLCAMWASPSAASRDEPNDPMMKRFEEWMAEYGRVYKDDDEKMRRFQIFKNNVKHIETFNSRNENSYTLGINQFTDMTKSEFVAQYTGVSLPLNIEREPVVSFDDVNISAVPQSIDWRDYGAVNEVKNQNPCGSCWSFAAIATVEGIYKIKTGYLVSLSEQEVLDCAVSYGCKGGWVNKAYDFIISNNGVTTEENYPYLAYQGTCNANSFPNSAYITGYSYVRRNDERSMMYAVSNQPIAALIDASENFQYYNGGVFSGPCGTSLNHAITIIGYGQDSSGTKYWIVRNSWGSSWGEGGYVRMARGVSSSSGVCGIAMAPLFPTLQSGANAEVIKMVSET
View 3D Structure Click here to view 3D model structure of allergen
Fasta Search in SDAP
Blast Swissprot database search at NCBI
Blast PDB database search at NCBI
Blast NR database search at NCBI
Ana c 2 - Statistics from Alphafold ( SI is sequence id, Best template format: PDB_ChainID)
Allergen Name pLDDT Score pTM Score Best PDB template %Seq ID Align length Seq length Query Range Sequence Range E-Value Bit Score Download Model
Ana c 2 90.9 0.8 6U7D_A 76.524 328 351 25 - 351 1 - 328 0 533 Download (SI: 859)
Ana c 2 - Alphafold Theoretical Model Structure
Model Structure
859_relaxed_rank_1_model_2.pdb


Coverage Plddt
Ana c 2 - Protein Sequence Properties!
Protein Sequence Protease cleavage sites PeptideCutter at ExPASy
2342496 Click here to process the data
Ana c 2 - PFAM Information
SeqID Aller ID AlnS AlnE EnvS EnvE PFAM ID Family Type Clan Description
859 774 37 94 37 94 PF08246 Inhibitor_I29 Domain No_clan Cathepsin propeptide inhibitor domain (I29)
859 774 123 334 123 335 PF00112 Peptidase_C1 Domain CL0125 Papain family cysteine protease
Where: AlnS= Alignment start position, AlnE= Alignment end position, EnvS= Envelope start position, EnvE= Envelope end position.

List of B-cell epitopes predicted by BepiPred method using a window size of 9 amino acids

Cleck here for epitopes predicted by BepiPred method
Ana c 2 - Epitope Information from published data
No. Position Epitope Sequence Epitope Type View epitope Search epitope in SDAP PD search in SDAP Cross-React search
No epitope information found!
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