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Department of Biochemistry and Molecular Biology Sealy Center for Structural Biology Computational Biology



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                SDAP - Structural Database of Allergenic Proteins
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Werner Braun      Submit new allergen information to SDAP
  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Access to SDAP is available free of charge for Academic and non-profit use.
Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu).
Secure access to SDAP is available from https://fermi.utmb.edu/SDAP
Allergen Info Description
Allergen ID 203
Allergen Scientific Name Api m 2
Allergen Species - Systematic Name Apis mellifera
Allergen Species - Common Name honey bee
Allergen Common source insects
Allergen Common name
Allergen Keywords Hyaluronidase; Hya; Hyaluronoglucosaminidase; EC 3.2.1.35
Allergen IUIS (Yes=1, No=0) 1
ID Allergen Name
Api m 2 - References
ID Reference
Pubmed ID: 7682712
Gmachl M, Kreil G, Bee venom hyaluronidase is homologous to a membrane protein of mammalian sperm. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3569-73.
Api m 2 - Protein Sequences
Source Link to source
SwissProt Q08169
Api m 2 - PDB Structure
PDB Id PDB Name PDB Entry Deposition Date Experiment Type Observation
203 160 1FCQ 19-JUL-00 X-ray diffraction resolution 1.6 A
203 161 1FCU 19-JUL-00 X-ray diffraction resolution 2.1 A
203 162 1FCV 19-JUL-00 X-ray diffraction resolution 2.65 A
203 290 2J88 2006-10-23 X-ray diffraction resolution 2.60 A complex with IgG (heavy and light chains)
2J88.pdb


Api m 2 - Sequence Search
Sequence Header Sequence
Api m 2
SDAP Sequence ID: 32
SDAP Allergen ID: 203
MSRPLVITEGMMIGVLLMLAPINALLLGFVQSTPDNNKTVREFNVYWNVPTFMCHKYGLRFEEVSEKYGILQNWMDKFRGEEIAILYDPGMFPALLKDPNGNVVARNGGVPQLGNLTKHLQVFRDHLINQIPDKSFPGVGVIDFESWRPIFRQNWASLQPYKKLSVEVVRREHPFWDDQRVEQEAKRRFEKYGQLFMEETLKAAKRMRPAANWGYYAYPYCYNLTPNQPSAQCEATTMQENDKMSWLFESEDVLLPSVYLRWNLTSGERVGLVGGRVKEALRIARQMTTSRKKVLPYYWYKYQDRRDTDLSRADLEATLRKITDLGADGFIIWGSSDDINTKAKCLQFREYLNNELGPAVKRIALNNNANDRLTVDVSVDQV
View 3D Structure Click here to view 3D model structure of allergen
Fasta Search in SDAP
Blast Swissprot database search at NCBI
Blast PDB database search at NCBI
Blast NR database search at NCBI
Expasy Blast Search
Api m 2 - Statistics from Alphafold ( SI is sequence id, Best template format: PDB_ChainID)
Allergen Name pLDDT Score pTM Score Best PDB template %Seq ID Align length Seq length Query Range Sequence Range E-Value Bit Score Download Model
Api m 2 89.3 0.81 1FCQ_A 100 350 382 33 - 382 1 - 350 0 733 Download (SI: 32)
Api m 2 - Protein Sequence Properties!
Protein Sequence Protease cleavage sites PeptideCutter at ExPASy
Q08169 Click here to process the data
Api m 2 - PFAM Information
SeqID Aller ID AlnS AlnE EnvS EnvE PFAM ID Family Type Clan Description
32 203 41 363 37 367 PF01630 Glyco_hydro_56 Domain CL0058 Hyaluronidase
Where: AlnS= Alignment start position, AlnE= Alignment end position, EnvS= Envelope start position, EnvE= Envelope end position.

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List of B-cell epitopes predicted by BepiPred method using a window size of 9 amino acids
Peptides predicted from BepiPred method can be used to search related peptides in SDAP using PD search and Cross-React method.
Please note: BepiPred Epitopes are predicted using BepiPred webserver implemented in IEDB Analysis Resource at http://tools.iedb.org/main/bcell/
Cleck here for epitopes predicted by BepiPred method

Api m 2 - Epitope Information from published data
Predicted B-Cell epitope using BCEP method for Api m 2
No. Position Epitope Sequence Epitope Type View epitope Search epitope in SDAP PD search in SDAP Cross-React search
No epitope information found!
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