The University of Texas Medical Branch
Department of Biochemistry and Molecular Biology Sealy Center for Structural Biology Computational Biology



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                SDAP - Structural Database of Allergenic Proteins
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Werner Braun      Submit new allergen information to SDAP
  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Access to SDAP is available free of charge for Academic and non-profit use.
Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu).
Secure access to SDAP is available from https://fermi.utmb.edu/SDAP
Allergen Info Description
Allergen ID 163
Allergen Scientific Name Asp f 16
Allergen Species - Systematic Name Aspergillus fumigatus
Allergen Species - Common Name
Allergen Common source fungi (moulds)
Allergen Common name Ascomycota Eurotiales
Allergen Keywords 43kDa protein; Asp f 9 homolog
Allergen IUIS (Yes=1, No=0) 1
ID Allergen Name
Asp f 16 - References
ID Reference
Pubmed ID: 15654824
Ramadan G, Davies B, Kurup VP, Keever-Taylor CA, Erratum in: Clin Exp Immunol. 2005 Apr;140(1):192-3. Generation of Th1 T cell responses directed to a HLA Class II restricted epitope from the Aspergillus f16 allergen. Clin Exp Immunol. 2005 Feb;139(2):257-67.
Pubmed ID: 11422136
Clin Exp Allergy. 2001 May;31(5):761-70. Banerjee B, Kurup VP, Greenberger PA, Johnson BD, Fink JN, Cloning and expression of Aspergillus fumigatus allergen Asp f 16 mediating both humoral and cell-mediated immunity in allergic bronchopulmonary aspergillosis (ABPA).
Asp f 16 - Protein Sequences
Source Link to source
GenBank 3643813
Asp f 16 - Theoretical Model Structure
Model ID PDB file PDB Snapshot PDB Snapshot 90 PDB Snapshot 180 PDB Snapshot 270 3D PDB View
334 GetModel Model Pic Model Pic Model Pic Model Pic Click here
Asp f 16 - Sequence Search
Sequence Header Sequence
Asp f 16
SDAP Sequence ID: 334
SDAP Allergen ID: 163
MYFKYTAAALAAVLPLCSAQTWSKCNPLAETCPPNKGLAASTCTADFTSASALDQWEVTAGKVPVGPQGAEFTVAKQGDAPTIDTDFYFFFGKAEVVMKAAPGTGVVSSIVLESDDLDEVDLVRLGGDTTQVQTNYFGKGDTTTYDRGTYVPVATPQETFHTYTIDWTKDAVTWSIDGAVVRTLTYNDAKGGTRFPQTPMRLRLAAGPAATPATPGHHRVGRWLDRLQRGTVHHVRQVRPYRERQPRRVLHLLGQLWLLAEHQVRRLRRYSSSSSVTSSTTSTASSASSTSSKTPSTSTLATSTKATPTPSGTSSGSNSSSSAEPTTTGGSGSSNTGSWLRLRLWLWLYSSTGSSTSAGASATPELSQGAAGSIKGSVTPALWCSAPSLPCWHSKQNDDFGLMHDTHHEGDVRTIHFGIGVSPSFGV
View 3D Structure Click here to view 3D model structure of allergen
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Asp f 16 - Statistics from Alphafold ( SI is sequence id, Best template format: PDB_ChainID)
Allergen Name pLDDT Score pTM Score Best PDB template %Seq ID Align length Seq length Query Range Sequence Range E-Value Bit Score Download Model
Asp f 16 63.75 0.57 6IBU_A 92.268 194 427 22 - 215 1 - 194 0 369 Download (SI: 334)
Asp f 16 - Alphafold Theoretical Model Structure
Model Structure
334_relaxed_rank_1_model_3.pdb


Coverage Plddt
Asp f 16 - Protein Sequence Properties!
Protein Sequence Protease cleavage sites PeptideCutter at ExPASy
3643813 Click here to process the data
Asp f 16 - PFAM Information
SeqID Aller ID AlnS AlnE EnvS EnvE PFAM ID Family Type Clan Description
334 163 57 217 50 224 PF00722 Glyco_hydro_16 Domain CL0004 Glycosyl hydrolases family 16
Where: AlnS= Alignment start position, AlnE= Alignment end position, EnvS= Envelope start position, EnvE= Envelope end position.

Welcome

Predicted B-Cell epitope using BCEP method for Asp f 16

Probe radius : 1.400

POLAR area/energy = 11486.11

APOLAR area/energy = 21922.56

Total area/energy = 33408.68

Number of surface atoms = 2225

Number of buried atoms = 979

Residues Predicted with high probability (in top five patches) are: 145,148,216,217,218,219,212,214,215,102,127,157,228,131 , and medium probability (next top five patches) are : 131,149,150,152,135,146,147,66,67,68,142,144,169,197 . Predicted residues are shown in red and green color stick representation.

Original PDB file 180.test.pdb
Original PDB file with surface residue only. All amino acid residue are replaced by their CB atom, in case of GLY CA atom is used. Solvent accessible surface area of each residue is stored in last column of the PDB file. 1180.test.txt
Patch drawn around the residues by patch analysis are stored in this file
How to read: Col 1: Patch No. Col 2: Center Res Name. Col 3: Sum(Pint*Area), Col 4: Sum(Psur*Area), Col 5: Total Residue, Col 6: Interface score, Col 7: Surface Score, Col 8: Max Interface Score, Col 9: Minimum Interface Score
180.test.tmppat
Residues predicted by patch analysis are stored in this file.
How to read: Col 1: Patch No. Col 2: Center Res Name. Col 3: Res Number Col 4: Neigbouring Res Name, Col 5: Sum(Pint*Area). Col 6: Sum(PSur*Area), Col 7: Sum(Area), Col 8: Similar no of residue in patch (e.g CYS, CYS = 2)
180.test.res
All residues scored by patch analysis are stored in this file.
How to read: Col 1: Patch No. Col 2: Center Res Name. Col 3: Sum(Pint*Area)/sum(Area), Col 4: Sum(Psur*Area)/sum(Area), Col 5: Total Residue
180.test.resALL

[For BCEP predicted results, please cite our websites http://fermi.utmb.edu/ http://curie.utmb.edu/ for your future publications (Negi et al., Bioinformatics, 23, 3397-3399, 2007 , Negi et al., J. Mol. Model., 13, 1157-1167, 2007; Negi et al., J. Mol. Model., 12, 921-929, 2006)]



List of B-cell epitopes predicted by BepiPred method using a window size of 9 amino acids
Peptides predicted from BepiPred method can be used to search related peptides in SDAP using PD search and Cross-React method.
Please note: BepiPred Epitopes are predicted using BepiPred webserver implemented in IEDB Analysis Resource at http://tools.iedb.org/main/bcell/
Cleck here for epitopes predicted by BepiPred method

Asp f 16 - Epitope Information from published data
No. Position Epitope Sequence Epitope Type View epitope Search epitope in SDAP PD search in SDAP Cross-React search
No epitope information found!
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