The University of Texas Medical Branch
Department of Biochemistry and Molecular Biology Sealy Center for Structural Biology Computational Biology


SDAP Home Page
SDAP Overview

Use SDAP
SDAP All
SDAP Food

SDAP Tools
FAO/WHO Allergenicity Test
FASTA Search in SDAP
Peptide Match
Peptide Similarity
Peptide-Protein PD Index
Aller_ML, Allergen Markup Language
List SDAP

About SDAP
General Information
Manual
FAQ
Publications
Who Are We
Advisory Board
New Allergen Submission form

Allergy Links

Our Software Tools
MPACK
FANTOM
GETAREA
InterProSurf
EpiSearch

Allergen Databases
WHO/IUIS Allergen Nomenclature database
FARRP Allergen Protein Database (University of Nebraska)
Allergen Database for Food Safety (ADFS)
COMPARE database
ALLFAM (Medical University of Vienna)
Allermatch (Wageninen University)
Allergome Database

Protein Databases
PDB
MMDB - Entrez
SWISS-PROT
NCBI - Entrez
PIR

Protein Classification
CATH
FSSP
iProClass
ProtoMap
SCOP
VAST

Bioinformatics Servers
BLAST @ NCBI
FASTA @ EMBL-EBI
Peptide Match @ PIR
ClustalW @ EMBL - EBI


                SDAP 2.0 - Structural Database of Allergenic Proteins
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Werner Braun      Submit new allergen information to SDAP
  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Access to SDAP is available free of charge for Academic and non-profit use.< Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu). Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen Info Description
Allergen ID 174
Allergen Scientific Name Pen ch 18
Allergen Species - Systematic Name Penicillium chrysogenum (formerly P. notatum)
Allergen Species - Common Name
Allergen Common source fungi (moulds)
Allergen Common name Ascomycota Eurotiales
Allergen Keywords vacuolar serine protease
Allergen IUIS (Yes=1, No=0) 1
ID Allergen Name
Pen ch 18 - References
ID Reference
Pubmed ID: 10231324
Shen HD, Lin WL, Tam MF, Wang SR, Tzean SS, Huang MH, Han SH, Characterization of allergens from Penicillium oxalicum and P. notatum by immunoblotting and N-terminal amino acid sequence analysis. Clin Exp Allergy. 1999 May;29(5):642-51.
Pen ch 18 - Protein Sequences
Source Link to source
GenBank 7963902
Pen ch 18 - Sequence Search :
Sequence Header Sequence
Pen ch 18
SDAP Sequence ID: 289
SDAP Allergen ID: 174
MKGFLSLTLLPLLVAASPVAVNSIHNDAAPILSSMTSKDIPDSYIVVFKKHVDPSSASAHQSWLQEVHTAHTGRMELKKRSLFGFDFEAFMGLKHTFHIAGSLLGYAGHFHEDVIEQIRRHPDVDYIEKDSEVRTMSEGSVEKNAPWGLARISHRESLSFGNFNKYLYAEEGGEGVDAYVIDTGANVKHVDFEGRANWGKTIPQGDADEDGNGHGTHCSGTIAGKKFGVAKKANVYAVKVLRSNGSGTMSDVVKGVEWAAEAHIKKSKKGDKKFKGSVANMSLGGGSSRTLDLAVNAAVDAGIHFAVAAGNDNADACNYSPAAAEKAITVGASTLADERAYFSNYGKCTDIFAPGLNILSTWVGSDHATNTISGTSMASPHIAGLLAYYVSLAPAKDSAYAVADVTPKQLKAALISVATEGTLTDIPSDTPNLLAWNGGGSANYTKILADGGYKAHNAETTVEDRIGIIIDSAEKAFHKELGAIYSEIKDAVSV
View 3D Structure Click here to view 3D model structure of allergen
Fasta Search in SDAP
Blast Swissprot database search at NCBI
Blast PDB database search at NCBI
Blast NR database search at NCBI
Pen ch 18 - Statistics from Alphafold ( SI is sequence id, Best template format: PDB_ChainID)
Allergen Name pLDDT Score pTM Score Best PDB template %Seq ID Align length Seq length Query Range Sequence Range E-Value Bit Score Download Model
Pen ch 18 85.8 0.64 5WSL_A 45.638 298 494 140 - 436 1 - 275 0 247 Download (SI: 289)
Pen ch 18 - Alphafold Theoretical Model Structure
Model Structure
289_relaxed_rank_1_model_4.pdb


Coverage Plddt
Pen ch 18 - Protein Sequence Properties!
Protein Sequence Protease cleavage sites PeptideCutter at ExPASy
7963902 Click here to process the data
Pen ch 18 - PFAM Information
SeqID Aller ID AlnS AlnE EnvS EnvE PFAM ID Family Type Clan Description
289 174 43 136 43 136 PF05922 Inhibitor_I9 Domain CL0570 Peptidase inhibitor I9
289 174 180 421 173 438 PF00082 Peptidase_S8 Domain No_clan Subtilase family
Where: AlnS= Alignment start position, AlnE= Alignment end position, EnvS= Envelope start position, EnvE= Envelope end position.

List of B-cell epitopes predicted by BepiPred method using a window size of 9 amino acids

Cleck here for epitopes predicted by BepiPred method
Pen ch 18 - Epitope Information from published data
No. Position Epitope Sequence Epitope Type View epitope Search epitope in SDAP PD search in SDAP Cross-React search
1 175-193 GVDAYVIDTGANVKHVDFE IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
2 180-198 VIDTGANVKHVDFEGRANW IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
3 201-225 TIPQGDADEDGNGHGTHCSGTIAGK IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
4 242-258 RSNGSGTMSDVVKGVEW IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
5 262-292 AHIKKSKKGDKKFKGSVANMSLGGGSSRTLD IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
6 358-378 ILSTWVGSDHATNTISGTSMA IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
7 401-410 AVADVTPKQL IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
8 411-434 KAALISVATEGTLTDIPSDTPNL IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
9 421-453 GTLTDIPSDTPNLLAWNGGGSANYTKILADGGY IgE Click here to find exact epitope Click here to find similar epitopes Click here for Cross-React search
289_relaxed_rank_1_model_4.pdb



Epitope Reference ( ID 23): C.-J. Yu, Y.-M. Chen, S.-N. Su, F. Forouhar, S.-H. Lee, and L.-P. Chow, Molecular and immunological characterization and IgE epitope mapping of Pen n 18, a major allergen of Penicillium notatum, Biochem. J. 2002, 363, 707-715.
SDAP Home Page | Search SDAP | SDAP Manual | SDAP FAQ | Contact  
UTMB | Search | Directories | UTMB Map | News | Employment | Sitemap 
This site published by Surendra Negi
Copyright   2001-2023  The University of Texas Medical Branch. Please review our privacy policy and Internet guidelines.