Department of Biochemistry and Molecular Biology

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SDAP - All Allergens

Go to: SDAP All allergens		Go to: SDAP Food allergens
Send a comment to Ovidiu Ivanciuc		Submit new allergen information to SDAP
Last Updated: Nov 1, 2021
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Access to SDAP is available free of charge for Academic and non-profit use. Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu). Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen Ara h 1

Translate to AllerML

Allergen	Ara h 1
Type	foods
Species - Systematic Name	Arachis hypogaea
Species - Common Name	peanut
Keywords	Vicilin; Clone P17
Class	IUIS

Ara h 1 - PubMed	Reference
Reference 1	Burks AW, Cockrell G, Stanley JS, Helm RM, Bannon GA. Recombinant peanut allergen Ara h I expression and IgE binding in patients with peanut hypersensitivity.J Clin Invest. 1995 Oct;96(4):1715-21.
Reference 2	Kolarich D, Altmann F. N-Glycan analysis by matrix-assisted laser desorption/ionization mass spectrometry of electrophoretically separated nonmammalian proteins: application to peanut allergen Ara h 1 and olive pollen allergen Ole e 1. Anal Biochem. 2000 Oct 1;285(1):64-75.

Ara h 1 - Protein Sequences

Source	Link to Source	View Sequence	FASTA@SDAP	BLAST@NCBI	BLAST@ExPASy	PROSITE@PIR
SwissProt	P43237	Go!	Go!	Go!	Go!	Go!
SwissProt	P43238	Go!	Go!	Go!	Go!	Go!

FASTA@SDAP: FASTA search against all SDAP allergen sequences performed at SDAP
BLAST@ExPASy: BLAST search performed at the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)
PROSITE@PIR: PROSITE search performed at PIR - Protein Information Resources

Ara h 1 - Protein Sequence Properties

Protein Sequence	Protease cleavage sites PeptideCutter@ExPASy
P43237	Go!
P43238	Go!

PeptideCutter@ExPASy: Protease cleavage sites predicted with PeptideCutter from the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)

Ara h 1 - Protein Similarity, Classification and Clustering

Protein Sequence	Superfamily	InterPro
P43237	Go!	Go!
P43238	Go!	Go!

Ara h 1 - Protein Models

3D Model	Source	Link to Source	View Sequence	View Alignment	Get Model	Picture	Picture+90	Picture+180	Picture+270	Jmol
Model 34	SwissProt	P43237	Go!	Go!	Go!	Go!	Go!	Go!	Go!	View!
Model 35	SwissProt	P43238	Go!	Go!	Go!	Go!	Go!	Go!	Go!	View!

These 3D allergen models are superseded by newer PDB structures.

Ara h 1 - Pfam domains

Sequence	Pfam sequence	Pfam family	Allergens from this Pfam family	Pfam database	Pfam region	First amino acid	Last amino acid
P43237
	AL11_ARAHY	PF00190	Go!	Pfam A	1	176	303
		PF00190: Cupin
	AL11_ARAHY	PF00190	Go!	Pfam A	1	176	303
		PF00190: Cupin
	AL11_ARAHY	PF00190	Go!	Pfam A	2	390	566
		PF00190: Cupin
P43238
	AL12_ARAHY	PF00190	Go!	Pfam A	1	182	309
		PF00190: Cupin
	AL12_ARAHY	PF00190	Go!	Pfam A	2	398	571
		PF00190: Cupin

Pfam is a database of multiple sequence alignments and hidden Markov models covering protein domains and families

Inspect MotifMate results for Ara h 1. AutoMotif contains a database of PCPMer motifs for allergens.
MotifMate home page
MotifMate summary
Browse MotifMate proteins
Browse MotifMate families

Ara h 1 - Sequences from the Entrez Nucleotides database

Link to GenBank	View Sequence
602435	Go!

Ara h 1 - PDB Structures

PDB Accession	Jmol	Deposition date	Experimental	Observation
3S7E	View!	2011-05-26	X-ray diffraction resolution 2.71 A
3S7I	View!	2011-05-26	X-ray diffraction resolution 2.35 A
3SMH	View!	2011-06-28	X-ray diffraction resolution 2.43 A	crystal structure of the major peanut allergen Ara h 1

Ara h 1 - Epitopes

No	Epitope	Exact Match @SDAP	Peptide Similarity @SDAP	Exact Match @PIR	Position	Type	Description
1	AKSSPYQKKT	Go!	Go!	Go!	25-34	IgE	When altered, amino acids shown in red lead to loss of IgE binding: AKSSPYQKKT
2	QEPDDLKQKA	Go!	Go!	Go!	48-57	IgE	When altered, amino acids shown in red lead to loss of IgE binding: QEPDDLKQKA
3	LEYDPRLVYD	Go!	Go!	Go!	65-74	IgE	When altered, amino acids shown in red lead to loss of IgE binding: LEYDPRLVYD Mutation: C71L
4	GERTRGRQPG	Go!	Go!	Go!	89-98	IgE	When altered, amino acids shown in red lead to loss of IgE binding: GERTRGRQPG
5	PGDYDDDRRQ	Go!	Go!	Go!	97-106	IgE	When altered, amino acids shown in red lead to loss of IgE binding: PGDYDDDRRQ
6	PRREEGGRWG	Go!	Go!	Go!	107-116	IgE	When altered, amino acids shown in red lead to loss of IgE binding: PRREEGGRWG
7	REREEDWRQP	Go!	Go!	Go!	123-132	IgE	When altered, amino acids shown in red lead to loss of IgE binding: REREEDWRQP
8	EDWRRPSHQQ	Go!	Go!	Go!	134-143	IgE	When altered, amino acids shown in red lead to loss of IgE binding: EDWRRPSHQQ
9	QPRKIRPEGR	Go!	Go!	Go!	143-152	IgE	When altered, amino acids shown in red lead to loss of IgE binding: QPRKIRPEGR
10	TPGQFEDFFP	Go!	Go!	Go!	294-303	IgE	When altered, amino acids shown in red lead to loss of IgE binding: TPGQFEDFFP
11	SYLQEFSRNT	Go!	Go!	Go!	311-320	IgE	When altered, amino acids shown in red lead to loss of IgE binding: SYLQEFSRNT Mutation: G315E
12	FNAEFNEIRR	Go!	Go!	Go!	325-334	IgE	When altered, amino acids shown in red lead to loss of IgE binding: FNAEFNEIRR
13	EQEERGQRRW	Go!	Go!	Go!	344-353	IgE	When altered, amino acids shown in red lead to loss of IgE binding: EQEERGQRRW
14	DITNPINLRE	Go!	Go!	Go!	393-402	IgE	When altered, amino acids shown in red lead to loss of IgE binding: DITNPINLRE
15	NNFGKLFEVK	Go!	Go!	Go!	409-418	IgE	When altered, amino acids shown in red lead to loss of IgE binding: NNFGKLFEVK
16	RRYTARLKEG	Go!	Go!	Go!	498-507	IgE	When altered, amino acids shown in red lead to loss of IgE binding: RRYTARLKEG
17	ELHLLGFGIN	Go!	Go!	Go!	525-534	IgE	When altered, amino acids shown in red lead to loss of IgE binding: ELHLLGFGIN
18	HRIFLAGDKD	Go!	Go!	Go!	539-548	IgE	When altered, amino acids shown in red lead to loss of IgE binding: HRIFLAGDKD
19	IDQIEKQAKD	Go!	Go!	Go!	551-560	IgE	When altered, amino acids shown in red lead to loss of IgE binding: IDQIEKQAKD
20	KDLAFPGSGE	Go!	Go!	Go!	559-568	IgE	When altered, amino acids shown in red lead to loss of IgE binding: KDLAFPGSGE
21	KESHFVSARP	Go!	Go!	Go!	578-587	IgE	When altered, amino acids shown in red lead to loss of IgE binding: KESHFVSARP
22	QNLRVAKISMPVNTPGQF	Go!	Go!	Go!	281-298	mAb-4A8	The 4A8 MAb bound linear peptides 18, 29, 33 and 34:
23	PHFNSKAMVIVVVNKGTG	Go!	Go!	Go!	446-463	mAb-4A8	The 4A8 MAb bound linear peptides 18, 29, 33 and 34:
24	EGDVFIMPAAHPVAINAS	Go!	Go!	Go!	506-523	mAb-4A8	The 4A8 MAb bound linear peptides 18, 29, 33 and 34:
25	ASSELHLLGFGINAENN	Go!	Go!	Go!	521-538	mAb-4A8	The 4A8 MAb bound linear peptides 18, 29, 33 and 34:
26	LVIQQGQATVTVANGNNR	Go!	Go!	Go!	236-253	mAb-13A4	The 13A4 MAb bound linear peptides 15, 28 and 29
27	MMLTCVEIKEGALMLPHF	Go!	Go!	Go!	431-448	mAb-13A4	The 13A4 MAb bound linear peptides 15, 28 and 29
28	PHFNSKAMVIVVVNKGTG	Go!	Go!	Go!	446-463	mAb-13A4	The 13A4 MAb bound linear peptides 15, 28 and 29

1. D. S. Shin, C. M. Compadre, S. J. Maleki, R. A. Kopper, H. Sampson, S. K. Huang, A. W. Burks, and G. A. Bannon, Biochemical and structural analysis of the IgE binding sites on Ara h 1, an abundant and highly allergenic peanut protein, J. Biol. Chem. 1998, 273, 13753-13759.
2. Hnasko RM, Lin AV, McGarvey JA, Mattison CP. Sensitive and selective detection of peanut allergen Ara h 1 by ELISA and lateral flow immunoassay. Food Chem. 2022 Dec 1;396:133657. doi: 10.1016/j.foodchem.2022.133657. Epub 2022 Jul 8. PMID: 35843000.
3. Burks AW, Shin D, Cockrell G, Stanley JS, Helm RM, Bannon GA. Mapping and mutational analysis of the IgE-binding epitopes on Ara h 1, a legume vicilin protein and a major allergen in peanut hypersensitivity. Eur J Biochem. 1997 Apr 15;245(2):334-9. doi: 10.1111/j.1432-1033.1997.t01-1-00334.x. PMID: 9151961.