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SDAP - All Allergens
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Ovidiu Ivanciuc      Submit new allergen information to SDAP
Last Updated: February 25, 2013  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Access to SDAP is available free of charge for Academic and non-profit use.
Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu).
Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen Api m 1

Translate to AllerML
AllergenApi m 1
Typeinsects
Species - Systematic NameApis mellifera
Species - Common Namehoney bee
Keywordsphospholipase A2; Phosphatidylcholine 2-acylhydrolase; EC 3.1.1.4
ClassIUIS

Api m 1 - PubMedReference
Reference 1Weber A, Schroder H, Thalberg K, Marz L, Specific interaction of IgE antibodies with a carbohydrate epitope of honey bee venom phospholipase A2. Allergy. 1987 Aug;42(6):464-70.
Reference 2Blaser K, Carballido J, Faith A, Crameri R, Akdis C, Determinants and mechanisms of human immune responses to bee venom phospholipase A2. Int Arch Allergy Immunol. 1998 Sep;117(1):1-10.
Reference 3Muller U, Akdis CA, Fricker M, Akdis M, Blesken T, Bettens F, Blaser K, Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):747-54.
Reference 4Carballido JM, Carballido-Perrig N, Kagi MK, Meloen RH, Wuthrich B, Heusser CH, Blaser K, T cell epitope specificity in human allergic and nonallergic subjects to bee venom phospholipase A2. J Immunol. 1993 Apr 15;150(8 Pt 1):3582-91.
Reference 5Kuchler K, Gmachl M, Sippl MJ, Kreil G, Analysis of the cDNA for phospholipase A2 from honeybee venom glands. The deduced amino acid sequence reveals homology to the corresponding vertebrate enzymes. Eur J Biochem. 1989 Sep 1;184(1):249-54.
Reference 6Buhot C, Chenal A, Sanson A, Pouvelle-Moratille S, Gelb MH, Menez A, Gillet Alteration of the tertiary structure of the major bee venom allergen Api m 1 by multiple mutations is concomitant with low IgE reactivity. Protein Sci. 2004 Nov;13(11):2970-8. Epub 2004 Sep 30.

Api m 1 - Protein Sequences
SourceLink to SourceView SequenceFASTA@SDAPBLAST@NCBIBLAST@ExPASyPROSITE@PIR
SwissProtP00630Go!Go!Go!Go!Go!
FASTA@SDAP: FASTA search against all SDAP allergen sequences performed at SDAP
BLAST@ExPASy: BLAST search performed at the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)
PROSITE@PIR: PROSITE search performed at PIR - Protein Information Resources

Api m 1 - Protein Sequence Properties
Protein SequenceProtease cleavage sites
PeptideCutter@ExPASy
P00630Go!
PeptideCutter@ExPASy: Protease cleavage sites predicted with PeptideCutter from the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)

Api m 1 - Protein Similarity, Classification and Clustering
Protein SequenceSuperfamilyInterPro
P00630Go!Go!

Api m 1 - PDB Structures
PDB AccessionJmolDeposition dateExperimentalObservation
1POCView!07-SEP-92X-ray diffraction resolution 2.0 Acomplex with transition-state analogue


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