The University of Texas Medical Branch
Department of Biochemistry and Molecular Biology Sealy Center for Structural Biology Computational Biology

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SDAP - All Allergens
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Ovidiu Ivanciuc      Submit new allergen information to SDAP
Last Updated: February 25, 2013  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Access to SDAP is available free of charge for Academic and non-profit use.
Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu).
Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen Ara h 1

Translate to AllerML
AllergenAra h 1
Typefoods
Species - Systematic NameArachis hypogaea
Species - Common Namepeanut
KeywordsVicilin; Clone P17
ClassIUIS

Ara h 1 - PubMedReference
Reference 1Burks AW, Cockrell G, Stanley JS, Helm RM, Bannon GA. Recombinant peanut allergen Ara h I expression and IgE binding in patients with peanut hypersensitivity.J Clin Invest. 1995 Oct;96(4):1715-21.
Reference 2Kolarich D, Altmann F. N-Glycan analysis by matrix-assisted laser desorption/ionization mass spectrometry of electrophoretically separated nonmammalian proteins: application to peanut allergen Ara h 1 and olive pollen allergen Ole e 1. Anal Biochem. 2000 Oct 1;285(1):64-75.

Ara h 1 - Protein Sequences
SourceLink to SourceView SequenceFASTA@SDAPBLAST@NCBIBLAST@ExPASyPROSITE@PIR
SwissProtP43237Go!Go!Go!Go!Go!
SwissProtP43238Go!Go!Go!Go!Go!
FASTA@SDAP: FASTA search against all SDAP allergen sequences performed at SDAP
BLAST@ExPASy: BLAST search performed at the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)
PROSITE@PIR: PROSITE search performed at PIR - Protein Information Resources

Ara h 1 - Protein Sequence Properties
Protein SequenceProtease cleavage sites
PeptideCutter@ExPASy
P43237Go!
P43238Go!
PeptideCutter@ExPASy: Protease cleavage sites predicted with PeptideCutter from the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)

Ara h 1 - Protein Similarity, Classification and Clustering
Protein SequenceSuperfamilyInterPro
P43237Go!Go!
P43238Go!Go!

Ara h 1 - Protein Models
3D ModelSourceLink to SourceView SequenceView AlignmentGet ModelPicturePicture+90Picture+180Picture+270Jmol
Model 34SwissProtP43237Go!Go!Go!Go!Go!Go!Go!View!
Model 35SwissProtP43238Go!Go!Go!Go!Go!Go!Go!View!
These 3D allergen models are superseded by newer PDB structures.

Ara h 1 - Pfam domains
SequencePfam sequencePfam familyAllergens from
this Pfam family
Pfam databasePfam regionFirst amino acidLast amino acid
P43237       
 AL11_ARAHYPF00190Go!Pfam A1176303
  PF00190: Cupin
 AL11_ARAHYPF00190Go!Pfam A1176303
  PF00190: Cupin
 AL11_ARAHYPF00190Go!Pfam A2390566
  PF00190: Cupin
P43238       
 AL12_ARAHYPF00190Go!Pfam A1182309
  PF00190: Cupin
 AL12_ARAHYPF00190Go!Pfam A2398571
  PF00190: Cupin
Pfam is a database of multiple sequence alignments and hidden Markov models covering protein domains and families

Inspect MotifMate results for Ara h 1. AutoMotif contains a database of PCPMer motifs for allergens.
MotifMate home page
MotifMate summary
Browse MotifMate proteins
Browse MotifMate families

Ara h 1 - Sequences from the Entrez Nucleotides database
Link to GenBankView Sequence
602435Go!

Ara h 1 - PDB Structures
PDB AccessionJmolDeposition dateExperimentalObservation
3S7EView!2011-05-26X-ray diffraction resolution 2.71 A 
3S7IView!2011-05-26X-ray diffraction resolution 2.35 A 
3SMHView!2011-06-28X-ray diffraction resolution 2.43 Acrystal structure of the major peanut allergen Ara h 1

Ara h 1 - Epitopes
NoEpitopeExact
Match
@SDAP
Peptide
Similarity
@SDAP
Exact
Match
@PIR
PositionTypeDescription
1AKSSPYQKKTGo!Go!Go!25-34IgE When altered, amino acids shown in red lead to loss of IgE binding: AKSSPYQKKT
2QEPDDLKQKAGo!Go!Go!48-57IgE When altered, amino acids shown in red lead to loss of IgE binding: QEPDDLKQKA
3LEYDPRLVYDGo!Go!Go!65-74IgE When altered, amino acids shown in red lead to loss of IgE binding: LEYDPRLVYD Mutation: C71L
4GERTRGRQPGGo!Go!Go!89-98IgE When altered, amino acids shown in red lead to loss of IgE binding: GERTRGRQPG
5PGDYDDDRRQGo!Go!Go!97-106IgE When altered, amino acids shown in red lead to loss of IgE binding: PGDYDDDRRQ
6PRREEGGRWGGo!Go!Go!107-116IgE When altered, amino acids shown in red lead to loss of IgE binding: PRREEGGRWG
7REREEDWRQPGo!Go!Go!123-132IgE When altered, amino acids shown in red lead to loss of IgE binding: REREEDWRQP
8EDWRRPSHQQGo!Go!Go!134-143IgE When altered, amino acids shown in red lead to loss of IgE binding: EDWRRPSHQQ
9QPRKIRPEGRGo!Go!Go!143-152IgE When altered, amino acids shown in red lead to loss of IgE binding: QPRKIRPEGR
10TPGQFEDFFPGo!Go!Go!294-303IgE When altered, amino acids shown in red lead to loss of IgE binding: TPGQFEDFFP
11SYLQEFSRNTGo!Go!Go!311-320IgE When altered, amino acids shown in red lead to loss of IgE binding: SYLQEFSRNT Mutation: G315E
12FNAEFNEIRRGo!Go!Go!325-334IgE When altered, amino acids shown in red lead to loss of IgE binding: FNAEFNEIRR
13EQEERGQRRWGo!Go!Go!344-353IgE When altered, amino acids shown in red lead to loss of IgE binding: EQEERGQRRW
14DITNPINLREGo!Go!Go!393-402IgE When altered, amino acids shown in red lead to loss of IgE binding: DITNPINLRE
15NNFGKLFEVKGo!Go!Go!409-418IgE When altered, amino acids shown in red lead to loss of IgE binding: NNFGKLFEVK
16RRYTARLKEGGo!Go!Go!498-507IgE When altered, amino acids shown in red lead to loss of IgE binding: RRYTARLKEG
17ELHLLGFGINGo!Go!Go!525-534IgE When altered, amino acids shown in red lead to loss of IgE binding: ELHLLGFGIN
18HRIFLAGDKDGo!Go!Go!539-548IgE When altered, amino acids shown in red lead to loss of IgE binding: HRIFLAGDKD
19IDQIEKQAKDGo!Go!Go!551-560IgE When altered, amino acids shown in red lead to loss of IgE binding: IDQIEKQAKD
20KDLAFPGSGEGo!Go!Go!559-568IgE When altered, amino acids shown in red lead to loss of IgE binding: KDLAFPGSGE
21KESHFVSARPGo!Go!Go!578-587IgE When altered, amino acids shown in red lead to loss of IgE binding: KESHFVSARP
D. S. Shin, C. M. Compadre, S. J. Maleki, R. A. Kopper, H. Sampson, S. K. Huang, A. W. Burks, and G. A. Bannon, Biochemical and structural analysis of the IgE binding sites on Ara h 1, an abundant and highly allergenic peanut protein, J. Biol. Chem. 1998, 273, 13753-13759.


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