The University of Texas Medical Branch
Department of Biochemistry and Molecular Biology Sealy Center for Structural Biology Computational Biology

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SDAP - All Allergens
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Ovidiu Ivanciuc      Submit new allergen information to SDAP
Last Updated: February 25, 2013  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Access to SDAP is available free of charge for Academic and non-profit use.
Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu).
Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen group: Ara h 2

Allergen Ara h 2.0101

Translate to AllerML
AllergenAra h 2.0101
Typefoods
Species - Systematic NameArachis hypogaea
Species - Common Namepeanut
KeywordsConglutin
ClassIUIS

Ara h 2.0101 - Protein Sequences
SourceLink to SourceView SequenceFASTA@SDAPBLAST@NCBIBLAST@ExPASyPROSITE@PIR
PubMed9186485Go!Go!Go!Go!Go!
GenBank15418705Go!Go!Go!Go!Go!
FASTA@SDAP: FASTA search against all SDAP allergen sequences performed at SDAP
BLAST@ExPASy: BLAST search performed at the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)
PROSITE@PIR: PROSITE search performed at PIR - Protein Information Resources

Ara h 2.0101 - Protein Sequence Properties
Protein SequenceProtease cleavage sites
PeptideCutter@ExPASy
9186485Go!
15418705Go!
PeptideCutter@ExPASy: Protease cleavage sites predicted with PeptideCutter from the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)

Ara h 2.0101 - Protein Models
3D ModelSourceLink to SourceView SequenceView AlignmentGet ModelPicturePicture+90Picture+180Picture+270Jmol
Model 283PubMed9186485Go!Go!Go!Go!Go!Go!Go!View!
Model 626GenBank15418705Go!Go!Go!Go!Go!Go!Go!View!
These 3D allergen models are superseded by newer PDB structures.

Ara h 2.0101 - Pfam domains
SequencePfam sequencePfam familyAllergens from
this Pfam family
Pfam databasePfam regionFirst amino acidLast amino acid
9186485       
 Q941R0_ARAHYPF00234Go!Pfam A142145
  PF00234: Protease inhibitor/seed storage/LTP family
15418705       
 Q941R0_ARAHYPF00234Go!Pfam A145148
  PF00234: Protease inhibitor/seed storage/LTP family
Pfam is a database of multiple sequence alignments and hidden Markov models covering protein domains and families

Inspect MotifMate results for Ara h 2.0101. AutoMotif contains a database of PCPMer motifs for allergens.
MotifMate home page
MotifMate summary
Browse MotifMate proteins
Browse MotifMate families

Ara h 2.0101 - Sequences from the Entrez Nucleotides database
Link to GenBankView Sequence
1236995Go!

Ara h 2.0101 - PDB Structures
PDB AccessionJmolDeposition dateExperimentalObservation
3OB4View!2010-08-06X-ray diffraction resolution 2.71 Amaltose-binding protein (MBP)-Ara h 2 fusion system

Ara h 2.0101 - Epitopes
NoEpitopeExact
Match
@SDAP
Peptide
Similarity
@SDAP
Exact
Match
@PIR
PositionTypeDescription
1HASARQQWELGo!Go!Go!15-24IgE 
2QWELQGDRGo!Go!Go!21-28IgE 
3DRRCQSQLERGo!Go!Go!27-36IgE 
4LRPCEQHLMQGo!Go!Go!39-48IgE 
5KIQRDEDSGo!Go!Go!49-56IgE 
6RDPYSPGo!Go!Go!59-64IgE 
7SQDPYSPSGo!Go!Go!65-72IgE 
8LQGRQQGo!Go!Go!117-122IgE 
9KRELRNLGo!Go!Go!127-132IgE 
10QRCDLDVEGo!Go!Go!143-150IgE 
J. S. Stanley, N. King, A. W. Burks, S. K. Huang, H. Sampson, G. Cockrell, R. M. Helm, C. M. West, and G. A. Bannon, Identification and mutational analysis of the immunodominant IgE binding epitopes of the major peanut allergen Ara h 2, Arch. Biochem. Biophys. 1997, 342, 244-253.
Ara h 2.0101 - Epitopes
NoEpitopeExact
Match
@SDAP
Peptide
Similarity
@SDAP
Exact
Match
@PIR
PositionTypeDescription
1RQQWELQGDRRCQSQLERANGo!Go!Go!19-38T-cell recognized by 3 subjects out of 8
2RRCQSQLERANLRPCEQHLMGo!Go!Go!28-47T-cell recognized by 2 subjects out of 8
3PYDRRGAGSSQHQERCCNELGo!Go!Go!73-92T-cell recognized by 3 subjects out of 8
4RCMCEALQQIMENQSDRLQGGo!Go!Go!100-119T-cell recognized by 2 subjects out of 8
I. N. Glaspole, M. P. de Leon, J. M. Rolland, and R. E. O'Hehir, Characterization of the T-cell epitopes of a major peanut allergen, Ara h 2, Allergy 2005, 60, 35-40.


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