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SDAP - All Allergens
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Ovidiu Ivanciuc      Submit new allergen information to SDAP
Last Updated: February 25, 2013  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Access to SDAP is available free of charge for Academic and non-profit use.
Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu).
Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen Hev b 3

Translate to AllerML
AllergenHev b 3
Typeothers
Species - Systematic NameHevea brasiliensis
Species - Common Namerubber (latex)
KeywordsSRPP; 22 kDa rubber particle protein; 22 kDa RPP; 27 kDa natural rubber
ClassIUIS

Hev b 3 - PubMedReference
Reference 1Alenius H, Palosuo T, Kelly K, Kurup V, Reunala T, Makinen-Kiljunen S, Turjanmaa K, Fink J. IgE reactivity to 14-kD and 27-kD natural rubber proteins in latex-allergic children with spina bifida and other congenital anomalies. Int Arch Allergy Immunol. 1993;102(1):61-6.
Reference 2Yeang HY, Cheong KF, Sunderasan E, Hamzah S, Chew NP, Hamid S, Hamilton RG, Cardosa MJ. The 14.6 kd rubber elongation factor (Hev b 1) and 24 kd (Hev b 3) rubber particle proteins are recognized by IgE from patients with spina bifida and latex allergy. J Allergy Clin Immunol. 1996 Sep;98(3):628-39.
Reference 3Wagner B, Krebitz M, Buck D, Niggemann B, Yeang HY, Han KH, Scheiner O, Breiteneder H. Cloning, expression, and characterization of recombinant Hev b 3, a Hevea brasiliensis protein associated with latex allergy in patients with spina bifida. J Allergy Clin Immunol. 1999 Nov;104(5):1084-92.
Reference 4Yeang HY, Ward MA, Zamri AS, Dennis MS, Light DR. Amino acid sequence similarity of Hev b 3 to two previously reported 27- and 23-kDa latex proteins allergenic to spina bifida patients. Allergy. 1998 May;53(5):513-9.
Reference 5Banerjee B, Kanitpong K, Fink JN, Zussman M, Sussman GL, Kelly KJ, Kurup VP, Unique and shared IgE epitopes of Hev b 1 and Hev b 3 in latex allergy. Mol Immunol. 2000 Aug-Sep;37(12-13):789-98.

Hev b 3 - Protein Sequences
SourceLink to SourceView SequenceFASTA@SDAPBLAST@NCBIBLAST@ExPASyPROSITE@PIR
SwissProtO82803Go!Go!Go!Go!Go!
FASTA@SDAP: FASTA search against all SDAP allergen sequences performed at SDAP
BLAST@ExPASy: BLAST search performed at the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)
PROSITE@PIR: PROSITE search performed at PIR - Protein Information Resources

Hev b 3 - Protein Sequence Properties
Protein SequenceProtease cleavage sites
PeptideCutter@ExPASy
O82803Go!
PeptideCutter@ExPASy: Protease cleavage sites predicted with PeptideCutter from the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)

Hev b 3 - Protein Similarity, Classification and Clustering
Protein SequenceSuperfamilyInterPro
O82803Go!Go!

Hev b 3 - Epitopes
NoEpitopeExact
Match
@SDAP
Peptide
Similarity
@SDAP
Exact
Match
@PIR
PositionTypeDescription
1AEEVEEERLKGo!Go!Go!2-11IgE 
2ERLKYLDFVRGo!Go!Go!8-17IgE 
3TLYLYAKDISGo!Go!Go!29-38IgE 
4LKPGVDTIENGo!Go!Go!41-50IgE 
5YYIPLEAVKFVGo!Go!Go!60-69IgE 
6VPPVIKQVSAGo!Go!Go!85-94IgE 
7APRIVLDVASGo!Go!Go!103-112IgE 
8GVQEGAKALYGo!Go!Go!118-127IgE 
9AVITWRALNKGo!Go!Go!138-147IgE 
10VPTAVYFSEKGo!Go!Go!159-168IgE 
11QGYRVSSYLPGo!Go!Go!179-188IgE 
B. Banerjee, K. Kanitpong, J. N. Fink, M. Zussman, G. L. Sussman, K. J. Kelly, and V. P. Kurup, Unique and shared IgE epitopes of Hev b 1 and Hev b 3 in latex allergy, Mol. Immunol. 2000, 37, 789-798.


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