The University of Texas Medical Branch
Department of Biochemistry and Molecular Biology Sealy Center for Structural Biology Computational Biology

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SDAP - All Allergens
Go to: SDAP All allergens       Go to: SDAP Food allergens
Send a comment to Ovidiu Ivanciuc      Submit new allergen information to SDAP
Last Updated: February 25, 2013  
Alphabetical listing of allergens: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Access to SDAP is available free of charge for Academic and non-profit use.
Licenses for commercial use can be obtained by contacting W. Braun (webraun@utmb.edu).
Secure access to SDAP is available from https://fermi.utmb.edu/SDAP

Allergen Cry j 2

Translate to AllerML
AllergenCry j 2
Typetree
Species - Systematic NamePinales; Cryptomeria japonica
Species - Common NameJapanese cedar, sugi
KeywordsPolygalacturonase; PG; Pectinase; EC 3.2.1.15
ClassIUIS

Cry j 2 - PubMedReference
Reference 1Sakaguchi M, Inouye S, Taniai M, Ando S, Usui M, Matuhasi T, Identification of the second major allergen of Japanese cedar pollen. Allergy. 1990 May;45(4):309-12.
Reference 2Namba M, Kurose M, Torigoe K, Hino K, Taniguchi Y, Fukuda S, Usui M, Kurimoto M. Molecular cloning of the second major allergen, Cry j II, from Japanese cedar pollen. FEBS Lett. 1994 Oct 17;353(2):124-8.
Reference 3Komiyama N, Sone T, Shimizu K, Morikubo K, Kino K. cDNA cloning and expression of Cry j II the second major allergen of Japanese cedar pollen. Biochem Biophys Res Commun. 1994 Jun 15;201(2):1021-8.
Reference 4Hashimoto M, Nigi H, Sakaguchi M, Inouye S, Imaoka K, Miyazawa H, Taniguchi Y, Kurimoto M, Yasueda H, Ogawa T. Sensitivity to two major allergens (Cry j I and Cry j II) in patients with Japanese cedar (Cryptomeria japonica) pollinosis. Clin Exp Allergy. 1995 Sep;25(9):848-52.
Reference 5Tamura Y, Kawaguchi J, Serizawa N, Hirahara K, Shiraishi A, Nigi H, Taniguchi Y, Toda M, Inouye S, Takemori T, Sakaguchi M. Analysis of sequential immunoglobulin E-binding epitope of Japanese cedar pollen allergen (Cry j 2) in humans, monkeys and mice. Clin Exp Allergy. 2003 Feb;33(2):211-7.

Cry j 2 - Isoallergens
NoIsoallergen
1Cry j 2.0101
2Cry j 2.0102

Cry j 2 - Protein Sequences
SourceLink to SourceView SequenceFASTA@SDAPBLAST@NCBIBLAST@ExPASyPROSITE@PIR
SwissProtP43212Go!Go!Go!Go!Go!
GenBank506858Go!Go!Go!Go!Go!
FASTA@SDAP: FASTA search against all SDAP allergen sequences performed at SDAP
BLAST@ExPASy: BLAST search performed at the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)
PROSITE@PIR: PROSITE search performed at PIR - Protein Information Resources

Cry j 2 - Protein Sequence Properties
Protein SequenceProtease cleavage sites
PeptideCutter@ExPASy
P43212Go!
506858Go!
PeptideCutter@ExPASy: Protease cleavage sites predicted with PeptideCutter from the Expert Protein Analysis System (ExPASy) proteomics server of the Swiss Institute of Bioinformatics (SIB)

Cry j 2 - Protein Similarity, Classification and Clustering
Protein SequenceSuperfamilyInterPro
P43212Go!Go!

Cry j 2 - Protein Models
3D ModelSourceLink to SourceView SequenceView AlignmentGet ModelPicturePicture+90Picture+180Picture+270Jmol
Model 98SwissProtP43212Go!Go!Go!Go!Go!Go!Go!View!
Model 308GenBank506858Go!Go!Go!Go!Go!Go!Go!View!


Cry j 2 - Pfam domains
SequencePfam sequencePfam familyAllergens from
this Pfam family
Pfam databasePfam regionFirst amino acidLast amino acid
P43212       
 MPA2_CRYJAPF00295Go!Pfam A186428
  PF00295: Glycosyl hydrolases family 28
506858       
 Q8H988_CRYJAPF00295Go!Pfam A186428
  PF00295: Glycosyl hydrolases family 28
Pfam is a database of multiple sequence alignments and hidden Markov models covering protein domains and families

Inspect MotifMate results for Cry j 2. AutoMotif contains a database of PCPMer motifs for allergens.
MotifMate home page
MotifMate summary
Browse MotifMate proteins
Browse MotifMate families

Cry j 2 - Sequences from the Entrez Nucleotides database
Link to GenBankView Sequence
506857Go!

Cry j 2 - Epitopes
NoEpitopeExact
Match
@SDAP
Peptide
Similarity
@SDAP
Exact
Match
@PIR
PositionTypeDescription
1PGNKKFVVNNLFFNGPCQPHFGo!Go!Go!96-116IgE 
2GQCKWVNGREICNDRDRPTAGo!Go!Go!166-185IgE 169-KWVNGREI-176 is recognized by IgE in humans, monkeys and mice
3SHIIYENVEMINSENPILINQFYCTGo!Go!Go!324-348IgE 
4YCTSASACQNQRSAVQIQDVGo!Go!Go!346-365IgE 
Y. Tamura, J. Kawaguchi, N. Serizawa, K. Hirahara, A. Shiraishi, H. Nigi, Y. Taniguchi, M. Toda, S. Inouye, T. Takemori, and M. Sakaguchi, Analysis of sequential immunoglobulin E-binding epitope of Japanese cedar pollen allergen (Cry j 2) in humans, monkeys and mice, Clin. Exp. Allergy 2003, 33, 211-217.
Cry j 2 - Epitopes
NoEpitopeExact
Match
@SDAP
Peptide
Similarity
@SDAP
Exact
Match
@PIR
PositionTypeDescription
1VDGIIAAYQNPASWKGo!Go!Go!120-134T-cell recognized by 11 out of 18 individuals
2NNRIWLQFAKLTGFTGo!Go!Go!135-149T-cell recognized by 9 out of 18 individuals
3IIQGLKLMNSPEFHLGo!Go!Go!195-209T-cell recognized by 10 out of 18 individuals
4ASKNFHLQKNTIGTGGo!Go!Go!240-254T-cell recognized by 12 out of 18 individuals
5SRAEVSYVHVNGAKFGo!Go!Go!290-304T-cell recognized by 9 out of 18 individuals
6CKDIKLSDISLKLTSGo!Go!Go!390-404T-cell recognized by 9 out of 18 individuals
7LKLTSGKIASCLNDNGo!Go!Go!400-414T-cell recognized by 12 out of 18 individuals
8GKIASCLNDNANGYFGo!Go!Go!405-419T-cell recognized by 11 out of 18 individuals
T. Sone, K. Morikubo, M. Miyahara, N. Komiyama, K. Shimizu, H. Tsunoo, and K. Kino, T cell epitopes in Japanese cedar (Cryptomeria japonica) pollen allergens: choice of major T cell epitopes in Cry j 1 and Cry j 2 toward design of the peptide-based immunotherapeutics for the management of Japanese cedar pollinosis. J. Immunol. 1998, 161, 448-457.


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